CIRRHOSIS

This study tests whether the blood thinner apixaban can safely dissolve blood clots in the portal vein that form more than a year after spleen surgery in people with cirrhosis. The study will enroll 20 participants and measure how many achieve complete or partial clot resolution.…

This study tests if memantine, a drug used for Alzheimer's, can help control advanced liver cancer in people with severe cirrhosis. About 12 adults with liver cancer that cannot be surgically removed will take memantine alone. Researchers will track how long the cancer stays stab…

This study tests a surgery that removes the spleen and disconnects certain blood vessels to treat complications of cirrhosis, like enlarged spleen and high blood pressure in the liver. The key twist is that surgeons use the vagus nerve as a guide to protect it, aiming to reduce c…

This study tests if weight-loss surgery is better than standard medical treatment for getting rid of nonalcoholic steatohepatitis (NASH) in obese people with advanced liver scarring. About 100 participants will be randomly assigned to either surgery or medical care. The main goal…

This study tests whether the drug carvedilol can reduce high blood pressure in the liver's blood vessels, a common problem in people with cirrhosis. High pressure raises the risk of life-threatening bleeding. The trial will enroll 30 adults with cirrhosis and use a special ultras…

This study tests whether rosuvastatin, a widely used cholesterol medication, can safely slow or prevent liver scarring and complications in people with cirrhosis. Researchers will enroll 256 adults with early-stage cirrhosis from causes like fatty liver, alcohol, or hepatitis. Pa…

This study tests whether capsules containing bacteria from healthy people can safely reduce alcohol cravings and drinking in adults with alcohol-related liver disease and cirrhosis. About 80 participants will receive either the bacteria capsules or a placebo. The goal is to see i…

This study looks at whether the blood thinner apixaban can safely dissolve blood clots in the portal vein (the main vein to the liver) that appear more than a year after laparoscopic spleen removal. It involves 20 adults with cirrhosis who had their spleen removed. The goal is to…

This study looks at people with cirrhosis (scarred liver) who also have severe muscle loss (sarcopenia) and need a procedure called TIPS to treat complications like bleeding. Half will get standard care, and half will also take branched-chain amino acid (BCAA) supplements for 6 m…

This study tests whether adding a statin (atorvastatin) to a standard beta-blocker can help people with decompensated cirrhosis, a serious form of liver disease. About 50 participants will receive either the combination or a beta-blocker plus placebo and be followed for 12 months…

This study tests whether adding the blood thinner apixaban to the standard drug carvedilol can prevent serious complications like bleeding, fluid buildup, and liver failure in people with cirrhosis and high blood pressure in the liver. About 220 adults with stable cirrhosis will …

This study tests whether giving copper supplements to people with cirrhosis (scarred liver) and low copper levels can improve liver function and reduce infections. About 30 adults with cirrhosis and low blood copper will receive either copper or a placebo for several weeks, then …

This study tests whether adding empagliflozin (a diabetes drug) to standard carvedilol treatment can prevent serious liver complications or death in people with cirrhosis and a stiff heart condition. About 400 adults aged 18–65 with cirrhosis and left ventricular diastolic dysfun…

This study tests whether a procedure called TIPS (a small tube placed in the liver to reroute blood flow) can help people with advanced liver disease (decompensated cirrhosis) achieve 'recompensation'—meaning the liver partially recovers and complications like fluid buildup or bl…

This study tests whether empagliflozin, a drug used for diabetes, can help people with cirrhosis (scarred liver) and ascites (belly fluid) get rid of extra salt and water. About 20 adults on stable diuretics will receive either the drug or a placebo for 14 days. The goal is to se…

This study tests whether a faster MRI scan (aMRI) plus a blood test (AFP) can find liver cancer earlier than the usual ultrasound plus AFP in 4,700 people with cirrhosis. The goal is to catch tumors at an early, more treatable stage and ultimately reduce deaths from liver cancer.…

This study tests whether a 3D MRI scan can accurately measure liver pressure in people with cirrhosis, potentially replacing the current invasive needle test. About 100 adults with confirmed cirrhosis will get both a 3D and 2D MRI, then a standard pressure measurement, to see whi…

This study tests whether a fast, no-dye MRI scan can find liver cancer earlier than the standard ultrasound in 300 people with cirrhosis who are at high risk. Participants will get both scans every 6 months for 2.5 years. The goal is to see if the MRI catches cancers that ultraso…

This study compares standard ultrasound monitoring to ultrasound plus a short, 10-minute MRI (Fast-MRI) for detecting early-stage liver cancer in people with cirrhosis who are at high risk. About 944 participants will be followed for several years to see which method finds more e…

This study is testing whether offering liver cancer screening every 6 months to people with cirrhosis can reduce deaths from liver cancer. About 617 participants in one region of Denmark will get an ultrasound and blood test. Their outcomes will be compared to similar patients in…

This study tests whether atorvastatin, a widely used cholesterol medication, can reduce the risk of developing liver cancer in people with advanced liver fibrosis or cirrhosis. About 60 adults at high risk will receive either atorvastatin or a placebo for up to 48 weeks. The main…

This study tests a device that uses mild electrical pulses on the skin to treat pain and depression in people with cirrhosis. About 30 adults with cirrhosis and chronic pain will be randomly assigned to receive either real or fake (sham) treatment for 10 weeks. The main goal is t…

This study tests whether giving a protein called albumin through a vein can improve thinking and memory in people with cirrhosis who have had episodes of hepatic encephalopathy (brain fog). Thirty adults with cirrhosis and mild cognitive problems will receive both albumin and a s…

This study tests a virtual cognitive behavioral therapy program designed to help people with cirrhosis who also have trouble sleeping. Ten adults with cirrhosis and insomnia will try the program from home and report how easy and helpful it is. The goal is to see if this approach …

This study tests whether a dietary supplement made from resistant potato starch can improve gut health and ease symptoms in 11 people with cirrhosis who have had episodes of hepatic encephalopathy (brain fog). Participants take the starch for 4 weeks while researchers measure cha…

This study will follow 3,000 adults with cirrhosis or who have had a liver transplant at a French hospital. Researchers will collect health data and samples over time to understand how the disease progresses, what complications arise, and how to improve care. No new treatments ar…

This study looks at 400 people with cirrhosis and sudden bleeding from enlarged veins in the food pipe. It compares getting an emergency scope within 6 hours versus waiting 6 to 24 hours. The goal is to see which timing better prevents repeat bleeding over the next 42 days.

This study looks at how quickly muscle proteins are made and broken down in people with cirrhosis (liver scarring). Researchers will use special tracers and a single muscle biopsy to measure these processes. The goal is to better understand muscle loss in cirrhosis, not to test a…

This study tests a computer system called CirrhosisRx that helps doctors make decisions for hospitalized patients with cirrhosis. About 2,100 adults with cirrhosis will be included, and the system will be compared to usual care. The goal is to see if the tool helps doctors follow…

This early-stage study looks at how the body processes the drug Saroglitazar in people with mild, moderate, or severe liver cirrhosis caused by cholestatic liver disease. About 30 adults aged 18 to 80 will take the drug once daily for 28 days. The goal is to measure drug levels a…

This study looks at how common muscle loss and weakness are in people with liver cirrhosis, and how malnutrition plays a role. Researchers will use ultrasound and grip strength tests to track changes over two years. The goal is to better understand these problems to improve futur…

This study looks at how taking potato starch or cellulose (a fiber) affects the gut bacteria of 30 Veterans who have both cirrhosis (liver scarring) and PTSD. The goal is to see if these supplements can change the types and amounts of bacteria in the gut. This is not a treatment …

This study is testing a new, less risky method to measure pressure in the liver's blood vessels using an endoscope with ultrasound. The goal is to see if this measurement can help predict serious problems like bleeding or fluid buildup in people with chronic hepatitis and cirrhos…

This study looks at 60 adults waiting for a liver transplant to see how frailty, nutrition, and mental health affect their recovery. Participants will do simple physical tests and answer questions about their daily life and well-being. The goal is to find which patients may need …

This study looks at bacteria living in the liver, blood, and stool of people with severe alcoholic hepatitis. Researchers want to see if these bacteria are linked to how well patients respond to treatment and their overall survival. The goal is to find new ways to treat this seri…

This study looks at why people with cirrhosis (scarring of the liver) often lose muscle and fat, which can make them sicker. Researchers will compare tissue samples from 16 cirrhosis patients getting a liver transplant and 16 healthy people having other abdominal surgery. They wa…

This study aims to learn more about Gastric Antral Vascular Ectasia (GAVE), a condition where stomach blood vessels enlarge and may bleed, causing pain and nausea. Researchers will use questionnaires and a breath test to measure symptoms and stomach function in 30 adults with GAV…

This study looks at whether the autonomic nervous system (which controls things like heart rate and digestion) can give clues about liver cancer. Researchers will measure nerve activity and psychological traits in 100 adults with cirrhosis. The goal is to find new ways to spot li…

This study follows 1500 people with cirrhosis and varices who also have a blood clot in the portal vein (the main vein to the liver). Researchers will track who gets better and what factors help the clot dissolve over 1 to 5 years. The goal is to better understand the disease and…

This study tests if a new, less invasive method using an endoscope with ultrasound can accurately measure blood pressure in the liver, compared to the standard method. About 40 adults with liver disease will have both measurements taken during one session. The goal is to see if t…

This study looks at whether low blood sugar during the night is connected to muscle loss (sarcopenia) in people with cirrhosis. Researchers will monitor blood sugar continuously in 200 adults with cirrhosis and measure muscle mass and strength. The goal is to gather data that cou…

This study aims to find genetic differences that make some people with fatty liver disease develop severe liver damage or cancer. Researchers will analyze DNA from blood and liver tissue of 2880 adults with advanced disease and compare it to controls. The goal is to create better…

This study looks at why a common liver procedure called TIPS might help people with cirrhosis who have severe muscle loss (sarcopenia). Researchers will measure changes in a protein called FGF21 and muscle mass in 132 adults over one year. The goal is to understand the mechanism,…