CIRRHOSIS

This study tests whether empagliflozin, a diabetes drug, can prevent liver scarring (fibrosis) from getting worse in people with chronic hepatitis B. About 106 adults with moderate to severe liver scarring will take either the drug or a placebo daily for three years. The goal is …

This study compares a drug called Angiotensin II to the usual treatment for raising blood pressure in people with liver disease who have a dangerous drop in blood pressure (shock). The goal is to see if Angiotensin II helps the heart and blood vessels work together better. About …

This study looks at whether simvastatin, a drug typically used for cholesterol, can help prevent serious liver problems in veterans with early-stage cirrhosis (scarred liver but no symptoms yet). About 142 participants will receive either simvastatin or a placebo to see if it red…

This study is testing a new blood test called Oncoguard™ Liver to see how well it finds liver cancer early in people who are at high risk, such as those with cirrhosis or hepatitis B. About 2,990 adults will take part, and the test's accuracy will be compared to standard ultrasou…

This study aims to see if a new scoring system called GAAD, which combines a patient's age, gender, and two blood markers, can detect liver cancer more accurately than current methods like ultrasound or standard blood tests. Researchers will enroll 2,100 adults with chronic liver…

This study tests whether simvastatin, a widely used cholesterol medication, can stop liver cancer from developing in people with liver cirrhosis. About 52 adults with confirmed cirrhosis will take simvastatin, and researchers will measure changes in blood markers linked to liver …

This early-stage trial is testing how safe radiation therapy is for people with liver cancer who also have liver damage from cirrhosis, chemotherapy, or surgery. The goal is to find the best dose that can kill cancer cells without causing severe side effects. The study includes 3…

This study looks at how liver cirrhosis affects trauma patients' outcomes, especially death and infections. Researchers will analyze data from over 4.7 million adults in the US treated for injuries between 2010 and 2018. The goal is to understand if having cirrhosis leads to wors…

This study tests whether an automatic reminder in the medical record helps doctors order liver ultrasounds for cirrhosis patients who need screening for liver cancer. About 1,300 adults with cirrhosis will take part. The goal is to see if the reminder increases the number of comp…

This study follows 1,222 adults with liver cirrhosis to understand why some people get worse. Researchers collect health data, images, and samples every 6 months to build models that predict serious complications like fluid buildup or confusion. The goal is to improve early detec…

This study observes 100 adults with cirrhosis to understand their dental health and any barriers to getting dental care. Participants receive a dental evaluation and cleaning, then are followed over time. The goal is to see how oral health relates to overall health in this group.

This study was designed to see if men with liver scarring (cirrhosis) and low blood pressure have different levels of the hormones estrogen and testosterone compared to men with cirrhosis but normal blood pressure. The goal was to better understand why low blood pressure happens …

This study aims to find the best way to get more veterans tested for colon and liver cancer. Researchers will compare two approaches: directly contacting people who need screening, or helping doctors fix delays in the testing process. Over 30,000 veterans and their healthcare pro…

This study follows up to 500,000 adults with chronic liver disease or cirrhosis to see how their condition changes over time and how well treatments work. Researchers will collect information from medical records and patient reports to improve care. No new treatments are being te…

This study re-examines 317 adults with type 2 diabetes who were first checked for fatty liver disease a few years ago. Researchers will use advanced scans and blood tests to see if their liver condition has improved, worsened, or stayed the same. The goal is to find patterns and …

This study tests a new decision aid tool to help VA medical centers adopt proven methods for screening patients with cirrhosis for liver cancer. About 8,020 veterans and clinicians will take part. The goal is to see if the tool improves screening rates, cancer detection, and long…