CIRRHOSIS

This study is testing whether empagliflozin, a medication for diabetes, can prevent or slow the progression of liver scarring (fibrosis and cirrhosis) in people with chronic hepatitis B. The 106 participants are already taking standard antiviral drugs but still have significant l…

This study is testing whether simvastatin, a medication commonly used to lower cholesterol, can help prevent liver failure in U.S. veterans who have early-stage cirrhosis (scarred liver) but no symptoms yet. About 142 participants will take either the drug or a placebo daily for …

This early-stage trial is testing whether a specialized form of radiation therapy is safe for people with liver cancer who also have poor liver function or a reduced amount of healthy liver tissue. The study will enroll 36 patients to find the highest safe dose of radiation that …

This study is testing a new blood test called Oncoguard™ Liver to see how well it can find liver cancer early in people at high risk. It will compare the test's accuracy to standard ultrasound screening. The goal is to see if this blood test can be a reliable tool for monitoring …

This study is testing a new blood test score, called the GAAD score, to see if it can help detect liver cancer (hepatocellular carcinoma) earlier in people at high risk. It will enroll 2,100 adults with chronic liver disease or cirrhosis who are already getting regular cancer scr…

This study is testing a new computer system designed to help doctors remember to order liver ultrasound scans for their patients with cirrhosis. The goal is to improve screening for liver cancer (hepatocellular carcinoma) by making it easier for doctors to place the right orders …

This study is testing if a widely used cholesterol-lowering drug called simvastatin can help prevent liver cancer in people who already have liver cirrhosis (scarring). It involves 52 participants who will take either the drug or a placebo (sugar pill) daily for 6 months. Researc…

This study is checking back with 317 people who have type 2 diabetes to see how their liver health has changed over several years. Researchers are not testing a treatment; instead, they are using scans and blood tests to understand why some people develop serious liver disease an…

This study aims to better understand chronic liver disease and cirrhosis by tracking the health journeys of 500,000 patients over time. Researchers will observe how the disease naturally progresses and how different treatments work in real-world settings. The study collects medic…

This study aims to better understand which adults with liver cirrhosis are most at risk for serious health complications. It will follow over 1,200 participants with liver scarring, checking in with them every six months to collect health data, images, and samples. The goal is to…

This study is testing a new computer-based decision tool designed to help hospitals overcome common barriers to implementing proven medical practices. It focuses on improving screening for liver cancer in veterans with cirrhosis. The research will compare the new tool against cur…

This study aims to find the best way for healthcare systems to get more veterans screened for colon and liver cancer. It will compare two approaches: directly helping patients navigate the screening process versus helping clinics fix system-level barriers. Researchers will track …