CIRRHOSIS

This study tests a new procedure using an endoscopic ultrasound to guide the injection of tiny particles into the spleen, aiming to reduce bleeding risk in people with liver cirrhosis and low platelets. About 50 adults with cirrhosis and a history of stomach bleeding will be enro…

This study looks at whether giving the protein albumin for three days, along with usual care, can prevent repeat bleeding in people with cirrhosis who have a sudden bleed from veins in the food pipe. About 60 adults will take part. The goal is to see if albumin lowers the chance …

This study tests whether bumetanide is better than furosemide at removing excess fluid in adults with cirrhosis who are hospitalized. About 500 participants will receive one of the two diuretics, and researchers will measure weight loss over the first week. The goal is to find a …

This study tests whether a digital prehabilitation app (HEAL-ME) combined with creatine and whey protein supplements can help maintain muscle health and reduce frailty in people with cirrhosis. About 100 participants will use the app and take supplements for at least 3 months. Th…

This study looks at whether a special 4D MRI scan can accurately measure blood flow and pressure in the liver without needing a catheter inserted into a neck vein. It will enroll 60 adults with cirrhosis, split into two groups: those with compensated cirrhosis and those needing a…

This study looks at whether a combination of ultrasound and spleen stiffness measurements can accurately detect dangerous high blood pressure in the liver (portal hypertension) without using an invasive needle test. Researchers will enroll 107 adults with liver cirrhosis and comp…

This study tests whether artificial intelligence (AI) can detect early signs of a common liver disease (MASLD) or cirrhosis by analyzing routine heart ultrasound images. Researchers will enroll 2,000 adults whose heart scans are flagged by the AI as high-risk for liver problems. …

This study tests whether capsules made from healthy people's gut bacteria can prevent future episodes of hepatic encephalopathy (a brain condition caused by liver disease) in veterans with cirrhosis. About 162 veterans will take these capsules or a placebo. The goal is to see if …

This study looks at whether tiny plastic particles (microplastics) build up in the liver and worsen cirrhosis and heart problems. Researchers will compare liver tissue from 30 people with cirrhosis to those without liver disease. The goal is to understand how plastic pollution ma…

This study will look back at medical records of 1,600 patients with liver cirrhosis who also have sepsis, a severe infection. The goal is to understand how doctors use antimicrobial drugs and how that affects survival. The main focus is on whether patients are alive 28 days after…

This study looks at how a substance called lactate changes the bacteria in your gut and how that might be linked to the worsening of liver cirrhosis. Researchers will compare 200 people with and without liver disease. No treatment is given—only observation and sample collection.…