New acid blocker may beat standard drug for Post-Banding ulcers in cirrhosis
NCT ID NCT07608536
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 3 trial tests whether vonoprazan, a newer acid-blocking drug, is better than rabeprazole at preventing ulcers and bleeding after endoscopic variceal band ligation (EVL) in people with cirrhosis. About 300 adults with esophageal varices will take one of the two drugs daily for two weeks. After treatment, doctors will use an endoscope to measure ulcer size and count. The goal is to see which drug more effectively reduces ulcer-related complications.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Vonoprazan and Rabeprazole
- What this could lead to
- If vonoprazan works better, it could offer a more effective way to prevent bleeding ulcers after variceal band ligation in people with cirrhosis.
- What could go wrong
- This is a phase 3 trial, but it's still early to know if vonoprazan is truly better. The study only follows patients for 2 weeks, so long-term benefits or risks are not assessed.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for CIRRHOSIS are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
King George Medical University
Lucknow, Uttar Pradesh, 226003, India
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can everyday drugs shield the liver from Cirrhosis's worst threats?
- Can extra doses of an old drug reverse liver scarring?
- A painless spleen scan could spot deadly vein bleeding risk without endoscopy
- Could a yellow tinge predict dangerous hospital infections?
- Muscle quality on MRI may foretell liver transplant success
- Melatonin may ease sleep and brain fog in liver disease — a trial puts it to the test