A painless spleen scan could spot deadly vein bleeding risk without endoscopy
NCT ID NCT07753577
First seen Aug 07, 2026 · Last updated Aug 07, 2026
Summary
This trial tests whether a new device, Pro9000X, can measure spleen stiffness to detect esophageal varices—enlarged veins in the esophagus that can bleed dangerously—in people with chronic liver disease. Currently, the only reliable way to diagnose these varices is an invasive endoscopy, which is uncomfortable and costly. The study will compare the device's spleen stiffness readings against endoscopy results in 246 patients to see if it can accurately identify who has varices and who is at high risk of bleeding. If successful, this could provide a quick, non-invasive screening tool to help prevent life-threatening bleeding episodes.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Pro9000X, a liver shear wave quantization detector that measures spleen stiffness non-invasively
- What this could lead to
- If proven accurate, this could offer a safe, painless alternative to endoscopy for spotting dangerous varices, potentially saving lives by enabling earlier detection and treatment.
- What could go wrong
- The test may not be accurate enough to replace endoscopy in all cases, and its performance could vary across different liver diseases. It is still under evaluation, so its real-world usefulness is not yet confirmed.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
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