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Ultrasound may replace scopes for bleeding risk in liver patients

NCT ID NCT07571876

Knowledge-focused Sponsor: Assiut University Source: ClinicalTrials.gov ↗

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This trial is taking on new participants right now.
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Registered, but not yet taking participants.
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Not open to general applications. Only people the study team invites can take part.
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Paused for now. It may or may not start again.
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Running, but no longer taking on new participants.
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The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

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Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

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Status unknown
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First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether a simple, non-invasive ultrasound can predict the risk of dangerous bleeding from enlarged veins in the esophagus (varices) in people with liver cirrhosis. Researchers will measure spleen size and a key blood vessel diameter on ultrasound and compare those results to the standard invasive scope exam. If successful, this could reduce the need for routine endoscopies in the future.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 165 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Apr 2026

An estimate. Start dates often move.

Expected to finish

May 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adult patients (aged 18 years and older) with chronic liver disease and established liver cirrhosis (including both compensated and decompensated, Child-Pugh classes A, B, and C) who are scheduled for an upper gastrointestinal endoscopy at AL-Rajhi University Hospital, Assiut University, Egypt.

Ages

18 years and older

Sex

Anyone

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult patients (age ≥18 years) with chronic liver disease and clinical/laboratory/radiological evidence of liver cirrhosis * Both compensated and decompensated cirrhosis (Child-Pugh classes A, B, and C) * Patients scheduled for upper gastrointestinal endoscopy * Patients who provide informed consent Exclusion Criteria: * Previous history of endoscopic variceal band ligation or sclerotherapy * Prior surgical portosystemic shunt procedures or transjugular intrahepatic portosystemic shunt (TIPS) * Hepatocellular carcinoma with portal vein thrombosis * Previous splenectomy * Patients receiving beta-blockers for variceal bleeding prophylaxis * Poor quality ultrasound images due to obesity or ascites * Refusal to participate in the study

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Conditions

The condition(s) this trial relates to.

cirrhosis of liver esophageal varices esophageal varices with bleeding liver disorder portal hypertension

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic liver disease (CLD) Esophageal bleeding Esophageal varices Liver cirrhosis Portal hypertension Ultrasonography Variceal bleeding

How to take part

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  1. The official record

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