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Can ultrasound spot early joint wear in diabetic nerve damage?

NCT ID NCT07801131

Knowledge-focused Sponsor: Istanbul Physical Medicine Rehabilitation Training and Research Hospital Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
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Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
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Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

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Status unknown
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First seen Sep 03, 2026 · Last updated Sep 04, 2026 · Updated 1 time

Summary

Researchers are using ultrasound to measure the thickness of ankle cartilage in people with type 2 diabetes who have nerve damage, and comparing it with healthy adults. Diabetic polyneuropathy may change how the lower limbs move, which could affect the ankle joint. The study includes 30 participants aged 40 to 70, half with confirmed diabetic nerve damage and half without. The goal is to see whether ultrasound can detect early joint changes that might otherwise go unnoticed.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Ultrasonography (non-invasive imaging to measure talar cartilage thickness)
What this could lead to
If cartilage thinning is detected early, it could help identify joint damage sooner in people with diabetic nerve disease.
What could go wrong
This is a small observational study, so findings may not apply broadly. Ultrasound measurements can vary, and the study does not test a treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

30 people

The number who actually took part.

Started

Jun 2026

Finished

Jul 2026

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population will consist of individuals aged 40-70 years diagnosed with type 2 diabetes mellitus for at least one year. Participants will include patients with electromyography (EMG)-confirmed diabetic polyneuropathy and no history of trauma or surgical intervention affecting the foot or ankle. Individuals with degenerative, rheumatologic, or infectious conditions of the lower extremity, as well as those with other systemic causes of neuropathy or skin conditions preventing ultrasonographic assessment, will be excluded.

Ages

40 to 70 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Individuals aged between 40 and 70 years * Individuals diagnosed with type 2 diabetes mellitus for at least 1 year * Diagnosis of diabetic polyneuropathy confirmed by electromyography (EMG) * No history of trauma or surgery affecting the ankle or foot Exclusion Criteria: * Presence of degenerative joint disease, rheumatologic disease, or infection affecting the foot or ankle * History of trauma or surgical intervention involving the foot or ankle * Presence of other systemic diseases that may cause neuropathy * Presence of any local skin lesion or deformity that would prevent ultrasonographic assessment

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Conditions

The condition(s) this trial relates to.

diabetic kidney disease diabetic neuropathy diabetic polyneuropathy peripheral nervous system disorder type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Ankle joint Diabetic polyneuropathy Talar cartilage thickness Type 2 diabetes mellitus Type 2 diabetes mellitus with diabetic nephropathy Ultrasonography

Contacts and locations

Locations

  • Istabul Physical Medicine and Rehabilitation Hospital

    Istanbul, bahçelievler, 34180, Turkey (Türkiye)

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