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Nanoparticle cleaning may calm pain after failed root canals in diabetic patients

NCT ID NCT07800403

Symptom relief Sponsor: Minia University Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 02, 2026 · Last updated Sep 03, 2026 · Updated 1 time

Summary

This trial tests whether adding nanoparticles to the standard disinfection during root canal retreatment reduces post-operative pain in people with type II diabetes. Participants are adults aged 18 to 40 with a failed root canal in a front tooth and an active infection at the root tip. Researchers will measure pain using a numeric rating scale at 24, 48, and 72 hours after the procedure. The goal is to see if this enhanced cleaning approach leads to a more comfortable recovery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
A nanoparticle-augmented disinfection protocol used during non-surgical root canal retreatment
What this could lead to
If it works, this approach could reduce pain and improve healing after root canal retreatment in people with type II diabetes.
What could go wrong
This is a small, early-stage trial with only 28 participants, so results may not apply broadly. The procedure carries standard risks of root canal treatment, such as discomfort or swelling.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 28 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2026

Expected to finish

Jul 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 40 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Diabetic patients type II of either gender aged from 18-40 years * Permanent mature Maxillary anterior teeth having a baseline periapical lesion (PAI score ≥3). Exclusion Criteria: * Immuno-compromised patients. * Pregnant women and smokers. * Patients with a history of antibiotic or analgesics intake within the few days before the endodontic treatment. * Teeth with root fractures or perforations. * Teeth with lesions connected to adjacent teeth.

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Post operative pain

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

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  3. A doctor treating you

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Contacts and locations

Locations

  • Minia University, Faculty of Dentistry

    RECRUITING

    Minya, Egypt

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