CIRRHOSIS

This study is investigating whether a standard medical procedure called TIPS, used to treat complications of advanced liver scarring (cirrhosis), can help the liver partially heal itself—a state called 'recompensation.' Researchers will follow 250 patients with cirrhosis who rece…

This small Mayo Clinic study is testing if a dietary supplement made from potato starch can help people with advanced liver disease (cirrhosis) who experience episodes of confusion, known as hepatic encephalopathy. Researchers want to see if the starch changes gut bacteria in a w…

This study is testing if the medication apixaban (a blood thinner) is safe and effective for treating and preventing blood clots in the main vein of the liver (portal vein thrombosis) in people with liver cirrhosis. It focuses on patients who had their spleen removed over a year …

This study is testing whether a drug called memantine, commonly used for Alzheimer's disease, can help control advanced liver cancer in patients who also have severe liver scarring (cirrhosis) and are too sick for standard chemotherapy. It will measure if the cancer stops growing…

This study aims to find out if performing a camera scope procedure (endoscopy) urgently within 6 hours is better than waiting 6 to 24 hours for patients with advanced liver disease who have a dangerous bleed from swollen veins in their stomach or esophagus. It will enroll 400 pat…

This small pilot study is testing whether giving copper supplements to people with advanced liver scarring (cirrhosis) is safe and can improve their health. It will involve 30 adult patients who have cirrhosis and low copper levels. Researchers want to see if raising copper level…

This study is testing whether a cholesterol-lowering drug called rosuvastatin can safely slow the progression of liver cirrhosis. It will involve about 256 adults with early-stage cirrhosis who are not yet experiencing severe complications. Participants will take either the drug …

This study is testing if adding the diabetes/heart drug empagliflozin to the standard heart drug carvedilol can better protect people with liver cirrhosis and a stiff heart. The main goal is to see if this combination prevents serious liver complications (like internal bleeding o…

This study is testing if adding a cholesterol-lowering statin drug to standard beta blocker treatment can help control advanced liver disease (decompensated cirrhosis). It will enroll 50 patients who already have serious liver complications. The goal is to see if this combination…

This study is testing if a heart medication called carvedilol can safely lower high blood pressure in the liver's portal vein (portal hypertension) in people with cirrhosis. The goal is to see if this reduces the risk of dangerous digestive bleeding. Researchers will measure the …

This study is testing whether empagliflozin, a medication typically used for diabetes, can help reduce dangerous fluid buildup in the abdomen (ascites) of people with advanced liver scarring (cirrhosis). Researchers will give the drug or a placebo to 20 patients for 14 days to se…

This study is for people with advanced liver disease (cirrhosis) who have lost significant muscle mass (sarcopenia) and need a standard procedure called TIPS to treat internal bleeding or fluid buildup. Researchers want to see if adding a specific nutritional supplement (branched…

This study aims to find out if a newer, endoscopy-based method for measuring pressure in the liver's blood vessels (EUS-PPG) is as accurate as the current standard test (HVPG). Researchers will compare both methods in 40 patients with advanced liver disease who are already schedu…

This study is testing whether adding a quick, 10-minute MRI scan to the standard 6-month ultrasound check can help find liver cancer at its earliest, most treatable stage in people with cirrhosis who are at high risk. Researchers will compare the two approaches in about 944 patie…

This study is testing if a faster, 20-minute MRI scan without dye is better than the standard ultrasound for finding liver cancer early in people with cirrhosis who are at high risk. Researchers will enroll 300 participants to receive both scans every six months for 30 months to …

This study aims to find a better, non-invasive way to measure pressure in the liver for people with cirrhosis. Researchers will compare two types of advanced MRI scans (3D and 2D) to see which one more accurately predicts liver pressure, which currently requires an invasive cathe…

This study is testing whether regular screening can help prevent deaths from liver cancer in people with cirrhosis (scarred liver). About 600 patients in one region of Denmark will get liver ultrasounds and a blood test every six months to try to catch cancer early. Researchers w…

This study is testing whether a low dose of the cholesterol-lowering drug atorvastatin (Lipitor) can reduce the risk of developing liver cancer in people who have advanced liver scarring (fibrosis or cirrhosis). About 60 adults with this high-risk condition will take either the s…

This study aims to find the best screening method to detect liver cancer early in people with cirrhosis. Researchers will compare standard ultrasound with a faster MRI scan, both done every six months, to see which finds cancer sooner. The goal is to catch cancer at earlier stage…

This small pilot study is testing whether a virtual sleep therapy program is practical and helpful for people with liver cirrhosis who struggle with insomnia. Researchers will enroll 10 participants to try a telehealth version of cognitive behavioral therapy for insomnia. The mai…

This study is testing whether a small, wearable electrical stimulation device can help manage chronic pain and depression in people with cirrhosis. Researchers will compare the real device to a fake one to see if it's practical and acceptable for patients to use at home. The main…

This study aims to understand why people with advanced liver scarring (cirrhosis) often lose significant muscle and fat, a condition linked to worse health outcomes. Researchers will compare small tissue samples taken during surgery from 16 cirrhosis patients and 16 healthy peopl…

This study aims to better understand liver cirrhosis and improve care for patients, including those who receive transplants. Researchers will follow 3000 patients over time, collecting health data and biological samples to identify what factors lead to complications and affect su…

This study aims to understand if leg muscle strength is linked to frailty and malnutrition in people with liver cirrhosis. Researchers will measure the leg strength of 60 patients and compare it to healthy volunteers. The goal is to see if a simple strength test could be a useful…

This study aims to understand how a standard liver procedure (TIPS) might help improve severe muscle loss (sarcopenia) in people with advanced liver cirrhosis. Researchers will follow 132 patients after their TIPS surgery, measuring a specific protein (FGF21) in their blood and t…

This study aims to understand if low blood sugar at night contributes to severe muscle loss in people with liver cirrhosis. Researchers will monitor 200 participants' blood sugar continuously and measure their muscle mass and strength. The goal is to gather evidence to design bet…

This study aims to understand if and how bacteria from the gut travel to the liver in people with severe alcoholic hepatitis, a life-threatening liver condition. Researchers will analyze bacteria from liver tissue, blood, and stool samples of 50 patients. The goal is to see if sp…

This study aims to understand why some people with fatty liver disease develop serious liver damage, like cirrhosis or cancer, while others do not. Researchers will analyze the complete DNA of 2880 participants, comparing people with advanced disease to those with only risk facto…

This study aims to understand why people with liver cirrhosis lose muscle mass. Researchers will use a new technique with special tracers and just one muscle biopsy to measure how muscle proteins are built up and broken down. The goal is to gather knowledge that could help develo…

This study aims to understand how physical weakness, poor nutrition, and mental health affect people before and after a liver transplant. Researchers will measure strength, walking ability, diet, and mood in 60 adults waiting for a transplant. The goal is to identify which patien…

This study aims to understand what factors help or hinder the natural resolution of dangerous blood clots in the main vein of the liver (portal vein) in patients with advanced cirrhosis and swollen veins in their esophagus. Researchers will look back at and follow 1,500 patients …

This study aims to better understand Gastric Antral Vascular Ectasia (GAVE), a condition where blood vessels in the stomach enlarge and can cause pain, nausea, and bleeding. Researchers will measure how often these symptoms occur and how they relate to how well the stomach emptie…

This study aims to understand how a drug called Saroglitazar is processed by the body in people with liver damage caused by a specific type of liver disease. It will compare 30 participants with mild, moderate, or severe liver damage to people with normal liver function. The main…