Could a diabetes drug shield the liver? new trial tests empagliflozin in cirrhosis
NCT ID NCT07322237
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether adding empagliflozin (a diabetes drug) to standard carvedilol treatment can prevent liver decompensation events and death in 400 adults with cirrhosis and left ventricular diastolic dysfunction (stiff heart). Participants will receive either empagliflozin plus carvedilol or a placebo plus carvedilol for up to 2 years. The goal is to see if the combination reduces complications like bleeding, ascites, or kidney injury.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Empagliflozin and Carvedilol
- What this could lead to
- If it works, this combination could reduce the risk of serious liver complications and improve survival in people with cirrhosis and heart stiffness.
- What could go wrong
- This is a single-center Phase 4 trial, so results may not apply broadly. The drug may cause side effects like infections or low blood pressure, and the benefit over carvedilol alone is unproven.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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PGIMER Chandigarh
RECRUITINGChandigarh, 160012, India
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