CARDIOMETABOLIC RISK FACTORS

This study tests whether adding empagliflozin (a diabetes drug) to standard carvedilol treatment can prevent liver decompensation events and death in 400 adults with cirrhosis and left ventricular diastolic dysfunction (stiff heart). Participants will receive either empagliflozin…

This study is testing whether a multi-strain probiotic supplement, taken alongside standard lifestyle advice, can improve liver health in people with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). The trial will enroll 80 adults with elevated liver enzymes and …

This study is testing a low-dose version of the drug semaglutide to help obese adults lose weight and improve heart health. The trial includes 60 Pakistani adults who are obese but do not have diabetes. Participants will receive weekly injections for 24 weeks, along with diet and…

This study is testing whether taking ginger capsules daily for 60 days can lower inflammation and oxidative stress in adults with excess body fat. Fifty participants will be randomly assigned to receive either ginger or a placebo. The goal is to see if ginger can improve markers …

This study tests whether vitamin D3 supplements can improve heart health in Chinese teenagers who are overweight or obese and have low vitamin D levels. 130 participants will receive either vitamin D3 or a placebo for 12 weeks. Researchers will measure changes in blood pressure, …

This study looks at whether adding a special whey protein supplement to a high-fat meal can improve markers of heart and brain health in postmenopausal women who are overweight and at moderate risk for heart disease. Sixteen women will each try the supplement and a placebo on sep…

This study compares two simple physical activity strategies—short walks after meals and brief activity snacks—to standard 30-minute exercise sessions in breast and prostate cancer survivors. The goal is to see which approach best controls blood sugar and is easiest to fit into da…

This study investigates how muscle fiber type and protein makeup relate to early insulin resistance, a key step before type 2 diabetes develops. Researchers will follow 250 healthy adults aged 20-30 for up to 20 years, using muscle biopsies, scans, and wearable sensors. The goal …

This study is testing different combinations of how often and for how long people should interrupt prolonged sitting to improve blood pressure and blood sugar. Over 300 adults will take part in a 9-hour lab visit where they sit and take short walking breaks at various frequencies…

This study tests whether drinking a ginger-based beverage every day can reduce inflammation and improve markers of heart health in adults with excess body fat. Researchers will measure changes in blood markers like interleukins and cholesterol. The study involves 50 participants …

This study tests five different group programs, all delivered remotely, to help adults with higher body weight eat healthy and be active. Some groups also include mindful eating, body image support, or finding enjoyable physical activities. The goal is to see which program people…