New surgical technique aims to prevent stomach issues after spleen removal

NCT ID NCT07462091

Recruiting now Disease control Sponsor: Northern Jiangsu People's Hospital Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a new surgical method that uses the vagus nerve to guide spleen removal and vein disconnection in people with cirrhosis and portal hypertension. The goal is to see if this nerve-guided approach reduces common post-surgery problems like diarrhea and delayed stomach emptying. Fifteen participants will be followed for three months to track digestive complications and quality of life.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Vagus nerve-guided laparoscopic splenectomy and azygoportal disconnection (surgical procedure)
What this could lead to: If successful, this surgical technique could reduce post-operative digestive problems like diarrhea and delayed stomach emptying, improving quality of life for cirrhosis patients.
What could go wrong: This is a small, early-phase study with only 15 participants, so results may not apply widely. Surgery carries risks like infection or bleeding, and the nerve-guided approach may not always prevent complications.

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Conditions

The condition(s) this trial relates to.

cirrhosis of liver Fibrosis hypersplenism portal hypertension

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CIRRHOSIS HYPERSPLENISM HYPERTENSION, PORTAL

Contacts and locations

Locations

Clinical Medical College of Yangzhou University
RECRUITING

Yangzhou, Jiangsu, 225001, China
Clinical Medical College, Yangzhou University
COMPLETED

Yangzhou, Jiangsu, 225001, China

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