Hypersplenism

This study tests a drug called soquelitinib in 15 people aged 16 and older with autoimmune lymphoproliferative syndrome (ALPS). The goal is to see if the drug can shrink an enlarged spleen or lymph nodes and improve low blood cell counts. Participants take the pill twice daily fo…

This study tests a procedure that uses microwave energy to destroy part of the spleen while temporarily blocking its main artery. The goal is to improve low blood cell counts in people with severe hypersplenism caused by cirrhosis. About 35 adults whose blood counts have not resp…

This study tests whether the blood thinner apixaban can dissolve blood clots in the portal vein that develop more than a year after laparoscopic spleen surgery in people with cirrhosis. Twenty participants will take apixaban twice daily, and doctors will use ultrasound or CT scan…

This study tests a new surgical method that uses the vagus nerve to guide spleen removal and vein disconnection in people with cirrhosis and portal hypertension. The goal is to see if this nerve-guided approach reduces common post-surgery problems like diarrhea and delayed stomac…

This study looks at whether removing only part of the spleen (instead of the whole spleen) can improve immune function in people with liver cirrhosis who have an overactive spleen (hypersplenism). About 30 adults will be enrolled. Researchers will measure immune markers and blood…