Hypersplenism

This early-stage study tests a new treatment using special immune cells (CAR-T cells) designed to reduce harmful antibodies that can prevent or damage bone marrow transplants. About 18 people with blood diseases who have these antibodies will receive the cells in increasing doses…

This study tests a new procedure using an endoscopic ultrasound to guide the injection of tiny particles into the spleen, reducing blood flow and lowering the risk of dangerous bleeding in people with liver cirrhosis. The goal is to see if this method is safer and more effective …

This study tests whether starting tube feeding right after a stem cell transplant can reduce severe gut graft-versus-host disease (GVHD) in people with blood cancers or disorders. About 112 participants will be randomly assigned to either standard care or early tube feeding. The …

This study follows 30 adults with liver cirrhosis who are having their spleen removed (laparoscopic splenectomy) to treat an enlarged spleen and low blood counts. Researchers will measure kidney function before surgery and for two years after to see if the surgery helps or harms …

This study follows 30 adults with liver cirrhosis, an enlarged spleen, and hypersplenism who are having their spleen removed by keyhole surgery. Researchers will measure changes in cholesterol and other blood fats before surgery and for two years afterward. The goal is to learn w…

This study follows 30 people with liver cirrhosis who need spleen surgery to treat bleeding from high blood pressure in the liver. Researchers will check their cholesterol and fat levels before and for two years after surgery. The goal is to see if the surgery improves abnormal f…