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Blood transfusion strategy could be refined for liver patients

NCT ID NCT06831565

Recruiting now Disease control Sponsor: Institute of Liver and Biliary Sciences, India Source: ClinicalTrials.gov ↗

First seen Jul 07, 2026 · Last updated Jul 08, 2026 · Updated 1 time

Summary

This trial tests whether using a more relaxed ROTEM threshold (a blood clotting test) can safely reduce the amount of blood products given to people with severe liver disease before medical procedures. Participants have cirrhosis or acute-on-chronic liver failure and will be randomly assigned to one of two ROTEM cut-off levels to guide transfusion decisions. The goal is to see if the higher cut-off lowers transfusion needs without increasing bleeding complications.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
ROTEM diagnostic test
What this could lead to
If successful, this could establish safer, more efficient guidelines for blood transfusions in liver disease patients, reducing unnecessary transfusions and associated risks.
What could go wrong
This is a single-center trial comparing two thresholds; results may not apply broadly. The relaxation of cut-offs could increase bleeding risk, and the study is not designed to prove long-term benefits.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Acute-On-Chronic Liver Failure cirrhosis of liver

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE-ON-CHRONIC LIVER FAILURE

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Institute of Liver & Biliary Sciences (ILBS)

    RECRUITING

    New Delhi, National Capital Territory of Delhi, 110070, India

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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