Can a blood pressure pill rescue failing kidneys in cirrhosis?
NCT ID NCT06937307
First seen Aug 19, 2026 · Last updated Aug 20, 2026 · Updated 1 time
Summary
This trial tests whether droxidopa, an oral medication that raises blood pressure, can improve kidney function in people hospitalized with cirrhosis and acute kidney injury. The study will compare droxidopa to a placebo in 75 participants, measuring changes in blood pressure and kidney function over 28 days of treatment plus 30 days of follow-up. The goal is to see if this simple pill could help kidneys recover without invasive procedures.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Droxidopa, an oral medication that raises blood pressure by converting to norepinephrine in the body
- What this could lead to
- If effective, droxidopa could offer a simple oral treatment to support kidney recovery in hospitalized cirrhosis patients with acute kidney injury, potentially reducing the need for intensive care.
- What could go wrong
- This is an early-phase trial with a modest size, so results may not be conclusive. The drug may not improve kidney function, and it could cause side effects like high blood pressure or heart rhythm issues.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Columbia University Irving Medical Center
RECRUITINGNew York, New York, 10032, United States
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