CIRRHOSIS

This study tested if using the vagus nerve to guide robotic surgery for removing the spleen and disconnecting certain blood vessels could reduce digestive problems like diarrhea and slow stomach emptying. Sixty adults with cirrhosis, an enlarged spleen, and bleeding from high blo…

This study looked at 310 adults with liver cirrhosis who developed a serious belly infection called spontaneous bacterial peritonitis. Researchers compared two antibiotics given through a vein: ciprofloxacin and ceftriaxone. The goal was to see which one works better at lowering …

This study explored whether a breath test could help find liver scarring (fibrosis), severe scarring (cirrhosis), or liver cancer early. Researchers collected breath samples from 56 adults with known or suspected liver problems. They used special machines to look for unique chemi…

This study tested whether a noninvasive device called FibroScan can accurately measure liver scarring (fibrosis) in children, potentially replacing the standard but painful liver biopsy. Researchers compared the device's readings to biopsy results in 264 children with various liv…

This study tested a simple strip test called PeriScreen to quickly diagnose infections in the belly fluid of people with cirrhosis. The goal was to see if the strip could detect infection as accurately as standard lab tests, but much faster. Researchers studied 649 patients and c…

This study tested whether an artificial intelligence (AI) program could find early signs of serious liver scarring (cirrhosis) by analyzing routine electrocardiogram (ECG) heart tests. Researchers compared doctors who received AI alerts about possible liver disease to doctors usi…

This study tested a smartphone app called PatientBuddy to see if it could help people with cirrhosis avoid being readmitted to the hospital within 30 days after discharge. The app was designed for both patients and their caregivers who live together. The goal was to reduce preven…

This study looked at whether doxycycline, a common antibiotic, can prevent spontaneous bacterial peritonitis (SBP) in people with cirrhosis. SBP is a serious infection of the belly fluid. The study included 841 adults with cirrhosis who were at risk for SBP. Researchers compared …

This study tested whether the drug rifaximin could prevent serious brain confusion (encephalopathy) in people with cirrhosis who had a TIPS procedure to lower blood pressure in the liver. About 211 adults took either rifaximin or a placebo daily. The goal was to see if the drug c…

This study tested a sleep medication called lemborexant in 82 adults with liver cirrhosis who had trouble sleeping. The goal was to see if the drug could improve sleep quality safely. The approach used a drug that works differently from common sleep aids to avoid liver-related ri…

This study tested whether a gentle electrical stimulation at specific acupoints (TEAS) helps people with cirrhosis tolerate an urgent endoscopy for suspected variceal bleeding. 180 participants were randomly assigned to receive active TEAS, sham TEAS, or standard care. The goal w…

This study tested two approved drugs, mirabegron and montelukast, in 78 adults with liver cirrhosis who also had overactive bladder and asthma. The goal was to see if the drugs are safe and help control bladder and asthma symptoms. Researchers used computer models to choose doses…

This study checked if a special MRI scan called LiverMultiScan gives the same results when a person is scanned twice on the same machine or on different machines. 61 adults with various liver diseases took part. The goal was to see if the scan reliably measures liver fat, iron, a…

This study looked at 60 adults with cirrhosis to see if a simple frailty test (Liver Frailty Index) matches actual leg muscle strength. Researchers measured quadriceps strength and checked for malnutrition and frailty using several tools. The goal is to find better ways to spot p…

This study tested whether two smartphone tools (PatientBuddy and EncephalApp) could help people with cirrhosis and their caregivers track symptoms and avoid preventable hospital readmissions within 30 days. Over 200 patients and their caregivers participated across multiple hospi…

This study looked at how bacteria from the intestines travel to the liver in people with hepatitis C and liver scarring. Researchers wanted to understand why this happens and if it makes liver disease worse. Thirty adults with stable liver disease took part, providing blood, stoo…

This study looked at how often hospitalized patients with cirrhosis experience pain. Researchers asked 30 adults with cirrhosis about their pain during a single 15-45 minute visit. The goal was to find out how common pain is in this group, since it is often overlooked. This is an…

This study looked at the genetic makeup of liver cancer in 808 patients. The goal was to find common gene changes and patterns that could help doctors better understand the disease. Researchers used tumor samples from patients who had surgery or other treatments. The results may …

This study reviewed medical records of 206 patients to compare how well endoscopic surgery works for early-stage upper gastrointestinal cancer in people with and without liver cirrhosis and varices. The goal was to understand the risks and benefits of this procedure in this high-…

This study compared two methods of liver biopsy—one using a needle through the skin and another using a thin tube through the mouth—to see which one patients found more comfortable. 102 adults with chronic liver disease took part. The goal was to measure patient experience using …

This study looked at 82 adults with cirrhosis and portal hypertension (high blood pressure in the liver) to find out how many have minimal hepatic encephalopathy (MHE) — a mild form of brain fog that can affect thinking. Researchers used simple blood tests and thinking exercises …

This study tested whether watching a video or reading text helps people with cirrhosis learn more about their condition. 218 adults with cirrhosis took a quiz before and after receiving either a text or video lesson. Researchers compared the change in scores to see which method w…

This study compared two methods for taking a liver biopsy and measuring blood pressure in the liver: the newer endoscopic ultrasound (EUS) approach versus the standard transjugular (TJ) method. 58 adults with chronic liver disease or portal hypertension took part. The goal was to…

This study looked at whether a heart ultrasound (echocardiography) can help doctors better manage liver cirrhosis patients who also develop sudden kidney injury. Researchers examined 28 patients to see how their hearts were working before giving them extra fluids. The goal was to…