Liver patients get brain protection: antibiotic may stop confusion after TIPS

NCT ID NCT02016196

Completed Prevention Sponsor: University Hospital, Toulouse Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether the antibiotic rifaximin could prevent a serious brain condition called hepatic encephalopathy in people with cirrhosis who undergo a TIPS procedure. The TIPS procedure helps reduce pressure in the liver but often leads to confusion and other brain issues. The trial involved 211 participants and compared rifaximin to a placebo to see if it could lower the risk of these brain complications.

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Conditions

The condition(s) this trial relates to.

cirrhosis of liver Fibrosis hepatic encephalopathy prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CIRRHOSIS

Contacts and locations

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Locations

CHRU Lille

Lille, France
CHU Angers

Angers, France
CHU Beaujon Clichy

Paris, France
CHU Bordeaux

Bordeaux, France
CHU Marseille

Marseille, France
CHU Nantes

Nantes, France
CHU Poitiers

Poitiers, France
CHU Rennes

Rennes, France
CHU Saint-Antoine

Paris, France
CHU Tours

Tours, France
Hôpital Jean Verdier

Bondy, France
Pitié Salpêtrière

Paris, France
UHToulouse

Toulouse, France, 31059, France