Liver patients get new hope: drug may stop brain fog after TIPS procedure

NCT ID NCT02016196

NEW Completed Prevention Sponsor: University Hospital, Toulouse Source: ClinicalTrials.gov ↗

First seen May 08, 2026 · Last updated May 08, 2026

Summary

This study tested whether the drug rifaximin could prevent serious brain confusion (encephalopathy) in people with cirrhosis who had a TIPS procedure to lower blood pressure in the liver. About 211 adults took either rifaximin or a placebo daily. The goal was to see if the drug could reduce the risk of this brain complication, which affects about 35% of patients after TIPS.

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Contacts and locations

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Locations

CHRU Lille

Lille, France
CHU Angers

Angers, France
CHU Beaujon Clichy

Paris, France
CHU Bordeaux

Bordeaux, France
CHU Marseille

Marseille, France
CHU Nantes

Nantes, France
CHU Poitiers

Poitiers, France
CHU Rennes

Rennes, France
CHU Saint-Antoine

Paris, France
CHU Tours

Tours, France
Hôpital Jean Verdier

Bondy, France
Pitié Salpêtrière

Paris, France
UHToulouse

Toulouse, France, 31059, France

Conditions

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CIRRHOSIS