University Hospital, Toulouse

This study looks at whether placing a temporary balloon in the stomach can help control asthma in people who are obese. About 84 adults with uncontrolled asthma and obesity will either get the balloon plus diet and exercise, or just diet and exercise. The main goal is to see if a…

This study compares two treatments for a type of adrenal gland tumor (Conn adenoma) that causes high blood pressure. One is laparoscopic surgery to remove the tumor, and the other is a less invasive procedure called radiofrequency ablation (RFA) that uses heat to destroy the tumo…

This early-phase study tests a new approach for people with Crohn's disease who have complex anal fistulas that didn't get better with standard treatments. Researchers will inject donor stem cells directly into the fistula to see if it's safe and can help close the tunnel. Nine a…

This study tests whether injecting stem cells from fat tissue into the fingers can heal painful, non-healing ulcers caused by scleroderma. About 32 adults with at least one such ulcer will receive either stem cells or a placebo. The main goal is to see if the ulcers heal complete…

This study looks at two ways to treat a fast, dangerous heart rhythm called ventricular tachycardia in people with coronary artery disease and relatively good heart function. One treatment uses a catheter to burn the tiny area causing the problem (radiofrequency ablation), and th…

This study tests whether performing intrauterine insemination (IUI) 42 hours after a hormone injection leads to more live births than the standard 36-hour timing. About 692 women with infertility will be randomly assigned to one of the two timings. The goal is to see if a slightl…

This study tests whether a bedside device called Quantra can help doctors manage bleeding during liver transplant surgery. The device measures blood clotting in real time to guide transfusion decisions. Researchers will compare this approach to standard care in 56 adults receivin…

This study looks at the best way to use zoledronic acid after stopping denosumab, a common osteoporosis treatment. Stopping denosumab can cause a rapid bone loss and increase fracture risk. The trial will compare a personalized, biomarker-guided approach versus a standard schedul…

This study aims to confirm if a test using a sample of amniotic fluid can accurately predict how well a baby's kidneys will work after birth. Researchers will analyze 78 fetuses with kidney and urinary tract malformations from hospitals across France. The goal is to see if this t…

This study looks at whether measuring a substance called D-lactate in spinal fluid can help doctors diagnose meningitis (a serious brain infection) in patients who have a tube draining fluid from their brain. About 185 adults with suspected meningitis will have their spinal fluid…

This study looks at whether emergency doctors using a lung ultrasound in the ambulance can improve how they diagnose and treat severe shortness of breath. About 40 adults with serious breathing trouble will be included. The goal is to see if the ultrasound helps doctors choose th…

This study is testing a new method to measure allergy-related substances (IgE) in blood and urine using a bioluminescence technique. Researchers will compare this new test to a standard one in about 1,376 people aged 6 months and older who have allergies. The goal is to see if th…

This study is testing a device that measures blood sugar levels by analyzing a person's breath, aiming to replace finger-prick tests. It involves 235 adults with type 2 diabetes or obesity. Researchers will collect breath samples to improve the device's accuracy.

This study is testing whether a special PET scan called 18F-FES PET/CT can find endometriosis lesions more accurately than standard MRI. The scan measures estrogen receptors in the lesions, which may help doctors understand pain levels and guide treatment. About 20 women with end…

This study looks at whether using lung and heart ultrasound can help emergency doctors give the right treatment faster to older adults (over 65) who come to the ER with sudden breathing trouble. About 504 participants will be enrolled. The goal is to see if ultrasound reduces the…

This study explores whether a simple hair test can tell if people with HIV are taking their medications as prescribed. Researchers will measure drug levels in different parts of a single hair strand from 30 participants who are known to be compliant. The goal is to see if hair ca…

This study aims to see if analyzing DNA from fluid left over after a lung nodule biopsy can better detect cancer. About 60 adults with small lung nodules (20 mm or less) will have a standard bronchoscopy, and the leftover fluid will be tested for cancer-related DNA changes. If su…

This study tests whether wearing a compression bandage after mastectomy can prevent lymphoceles—painful fluid collections under the skin. About 84 adults having mastectomy for breast cancer will be randomly assigned to receive either a drain plus compression bandage or a drain al…

This study tests the WHO's ICOPE program, which screens older adults for early signs of decline in mobility, memory, nutrition, vision, hearing, and mood. If problems are found, a personalized care plan is created. The goal is to see if this approach can prevent or delay loss of …

This study tests whether taking a daily low-dose aspirin (150 mg) starting early in pregnancy can prevent preterm preeclampsia in first-time mothers who became pregnant through assisted reproductive technology (ART) like IVF. About 1,164 women will be randomly assigned to receive…

This study tests whether a steroid injection into the wall of the meniscus, guided by ultrasound, can quickly relieve knee pain caused by a degenerative meniscus tear. About 152 adults with persistent knee pain will receive either the steroid or a placebo injection. The main goal…

This study tests whether a personalized brain-training therapy (neurofeedback) can improve arm movement in people who recently had a stroke. About 44 participants will either receive standard or personalized neurofeedback during 15 sessions over three weeks. The goal is to see if…

This study is testing whether a single session of cardiac coherence (a slow, paced breathing exercise) done right before an MRI can lower anxiety in people who are nervous about the scan. About 60 adults with high MRI-related anxiety will participate. The goal is to see if this s…

This study looks at whether a two-week intensive dance program can improve learning in children with cerebral palsy. Six children aged 6 to 17 will take dance classes and be tested on motor, thinking, and social skills. The goal is to see if rhythmic movement helps them learn new…

This study tests whether a support group for siblings (ages 2-18) of teenagers with anorexia nervosa is acceptable and helpful. About 24 siblings will attend group sessions and fill out questionnaires about their experience and quality of life. The goal is to see if this kind of …

This study tests whether a machine that helps people cough (called a mechanical in-exsufflator) can improve breathing in 36 people with ALS who have a weak cough. Participants will use the device several times a week for a month. The goal is to see if their cough strength stays s…

This study looks at whether a single educational session about the benefits of physical activity can help people with inflammatory bowel disease (IBD) exercise more. The study involves 71 adults with IBD who are in remission. Researchers will measure their activity levels and qua…

This study tests whether a 6-month adapted physical activity program can improve exercise capacity in children and teenagers with Marfan syndrome. About 30 participants aged 7 to 17 will take part. The program focuses on safe, tailored exercises to help them move better and feel …

This study tests a wearable neuroprosthesis that uses mild electrical stimulation to help stroke survivors open their hand. Two participants will use the device at home for one year to see if it improves daily activities and quality of life. The goal is to understand how well the…

This study tests a 100% remote education program for adults with moderate depression who recently started antidepressants. The program aims to help them stick with their medication and improve their symptoms. Researchers will compare the program to usual care in 220 participants …

This study tests whether learning music—rhythm, singing, and body movements—can improve attention and thinking in people with schizophrenia. About 120 adults with stable schizophrenia will take part. The goal is to see if music-based training is a more engaging and effective way …

This study looks at whether a guided exercise program can improve quality of life and lower healthcare costs for women with breast cancer who are undergoing treatment like surgery, chemo, or radiation. About 866 women will be split into two groups: one gets the exercise program, …

This study looks at whether a special wrap treatment, done by a nurse after a bath, can reduce skin discomfort in people with moderate to very severe hereditary ichthyosis. About 34 adults will receive three wraps over a short period. The main goal is to see if at least a 3-point…

This study tests whether a 6-month adapted physical activity program can improve exercise capacity and quality of life in 30 children and teens with osteogenesis imperfecta (brittle bone disease). Participants will do safe, supervised exercises designed for their condition. The g…

This study tests a special hand device that helps people who had a stroke and cannot open their hand to grab things. The device is designed to let users control it themselves to pick up, move, and release objects like a glass or spoon. Researchers will compare how well 30 partici…

This study tests custom-made 3D-printed stents for people with narrowed airways. The stents are designed to fit each person's unique airway shape, which may reduce serious complications like stent movement or blockage. About 30 adults with severe symptoms will receive the stent a…

This study tests a home grip assistance glove (SaeboGlove) to help stroke survivors use their weaker arm in everyday tasks. About 100 adults who had a stroke more than three months ago and have trouble opening their hand will try the glove at home. Researchers will compare how we…

This study tests whether a 4-week home-based cognitive strategy program can help adults with chronic stroke become more independent in daily activities like dressing and cooking. Researchers will enroll 18 participants to see if the program is practical and effective. The goal is…

This study looks at whether women with high blood pressure who take their medication as prescribed have fewer sexual problems than those who skip doses. Researchers will survey 348 women and test their blood to check drug levels. The goal is to understand if sticking to medicatio…

This study looks at why some people with Parkinson's disease feel pain. Researchers will use brain scans to see how serotonin, a natural chemical, is involved. About 34 adults with Parkinson's will take part. The goal is to better understand pain, not to test a new treatment.

This study collects blood samples and health data from 1000 people with rare neurological diseases that may be caused by the immune system attacking the body. The goal is to build a large biobank that researchers can use to discover new biomarkers and develop better treatments. P…

This study aims to create a large collection of blood samples and medical data from 800 people with autoimmune or inflammatory skin diseases. Researchers will use these samples to find new biomarkers and better understand what causes these conditions. The goal is to help develop …

This study examines bacteria living on heart valves in 200 patients having aortic valve surgery. Researchers want to see if these bacteria are linked to serious complications after surgery, like stroke or infection. The goal is to better understand how oral health and heart disea…

This study collects blood samples from 1500 adults at risk for heart disease to discover new biomarkers that can predict future heart attacks, strokes, or blocked leg arteries. Participants are seen at a specialized prevention center and provide samples and health data at the sta…

This study compares using plain water versus the usual polyethylene glycol (PEG) solution as a bowel preparation for magnetic resonance enterography (MRE) in people with Crohn's disease. About 194 participants will receive either water or PEG before their MRI, and researchers wil…

This study is looking for 400 people with multiple sclerosis to see if a substance in urine, called S1P, can tell doctors how well the bladder is working. Right now, checking for bladder problems requires a tube inserted into the bladder, which is uncomfortable. If S1P levels in …

This study looks at how people with severe memory problems due to brain damage in the temporal lobe can still learn new information. Researchers will use memory tests and MRI scans to find which parts of the brain help with this learning. The goal is to understand the brain's abi…

This study looks at how sleeping at high altitude (2,877 meters) affects the sleep of 32 employees at the Pic du Midi observatory. Researchers will use sleep monitoring to compare nights spent at the summit with nights spent at home. The goal is to understand sleep changes in peo…

This study aims to describe the typical care journey for 200 adults with head and neck cancer who undergo facial reconstruction using a free bone flap. Researchers will analyze national health data to map hospital visits, treatments, and medications. The goal is to better underst…

This study follows 2000 people with multiple myeloma in the West-Occitanie region of France to see what treatments they actually receive and how those treatments affect their disease and daily life. Researchers want to fill the gap between strict clinical trials and real-world ca…

This study tests whether a monthly monitoring program (ICOPE) can help detect early signs of decline in people over 70 with multiple myeloma. The goal is to prevent loss of independence. About 30 participants will use a digital app or chatbot for one year to track their health.

This study will enroll 5,000 adults with kidney disease or at risk for it, including transplant recipients. Researchers will analyze blood and urine samples to find molecular patterns that predict disease progression, complications, or treatment response. The goal is to improve r…

This study looks at a common problem after bowel surgery called postoperative ileus, where the bowel temporarily stops working. The researchers want to test a scoring system called IFEED to see if it can better define this condition and predict how long patients stay in the hospi…

This study looks at the genes active in lymphedema, a condition that causes painful swelling in arms or legs. Researchers will compare tissue from affected and healthy limbs in 60 adults with primary or secondary lymphedema. The goal is to understand what goes wrong in the lympha…

This study looks at healthy adults over 60 to see if brain scans and eye-tracking tests can predict whether thinking skills stay sharp or decline over time. Researchers will measure a small brain area called the locus coeruleus and link it to memory and attention. No treatment is…

This study is a national registry in France that collects information on adults newly diagnosed with immune thrombocytopenia (ITP) or autoimmune hemolytic anemia (AIHA). It aims to describe how these diseases progress and how well treatments work in real life. No new treatment is…

This study takes skin or blood cells from 20 people with eye malformations and turns them into stem cells, which are then grown into tiny 3D eye-like structures (organoids) in a dish. Researchers will study these mini eyes to understand what goes wrong during development and test…

This study collects tumor, blood, urine, and stool samples from 1000 adults with suspected or confirmed bladder cancer. The samples are stored securely for future biological and genetic research. The goal is to build a resource that can help scientists better understand the disea…

This study is looking at whether a rare condition called carotid web, which is a small flap in the neck artery that can raise stroke risk, runs in families. Researchers will use a simple neck ultrasound to screen close relatives (like siblings or children) of people already diagn…

This study aims to improve how acyclovir is dosed in people with obesity. Researchers will measure lean body mass and kidney function in 20 healthy volunteers with different BMIs to see if these factors predict how the body clears the drug. The goal is to create better dosing gui…

This study is creating a large collection of blood and other body fluid samples from 3,000 people with lung nodules or lung cancer. Researchers will analyze these samples to find new biomarkers that could help diagnose lung cancer earlier, predict how the disease will progress, o…

This study collects blood samples from 2,000 people with rheumatoid arthritis, psoriatic arthritis, spondyloarthritis, or osteoporosis. Researchers will look for biological markers that can predict how well a patient responds to treatment. The goal is to improve future care, not …

This study looks at how Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome, a rare condition where the uterus and vagina are underdeveloped, affects women's overall quality of life, sexual health, and mental well-being. Researchers will compare 102 women with MRKH to a control group …

This study looks at whether detecting a specific type of brain wave, called fast-ripples, can help doctors better plan surgery for people with epilepsy that doesn't improve with medication. About 440 adults will take part, with half getting the new brain wave test during their st…

This study looks at how often children who had very high bilirubin levels (jaundice) as babies develop permanent tooth stains. Researchers will check 120 children with certain liver conditions to see if the stains affect their quality of life. The goal is to gather evidence to he…

This study talks to children aged 10 and older who had Guillain-Barré Syndrome (GBS) two to five years ago. Researchers want to understand how they remember the illness and how it affects their emotions and daily life now. About 25 children will share their stories in interviews …

This study collects tumor samples and medical information from 1,500 people with pancreatic cancer. The goal is to build a large biobank that researchers can use to better understand the disease and develop new treatments. Participants undergo standard diagnostic procedures, and …

This study looks at whether adding a steady beat helps children with cerebral palsy or coordination disorders learn dance moves more easily. About 68 children aged 8 to 16 will take part, including those with and without movement problems. Researchers will compare how well they r…

This study tests a new high-resolution mapping system to find the exact location of the heart's electrical nodes in people with a fast heartbeat condition called AVNRT. Researchers will compare maps from 20 patients (10 with AVNRT, 10 without) to see if the system can guide more …

This observational study looks at the bacteria in dental plaque of 170 people with obesity (BMI 30+) who are scheduled for bariatric surgery. Researchers want to see if the types and amounts of mouth bacteria differ between those with obesity (BMI 30-35) and those with morbid obe…

This study collects extra blood and urine samples from 300 people with Marfan syndrome or related conditions. The samples are stored for research only, with no direct treatment or intervention. The goal is to better understand the disease and find factors that predict how it will…

This observational study is recruiting 30 women who have had at least three miscarriages. Researchers will check their gum health and collect saliva and plaque samples to measure bacteria levels. The goal is to see if certain mouth bacteria are more common in these women. No trea…

This study aims to collect blood samples and medical information from 3,000 people with autoimmune diseases like lupus, scleroderma, and myositis. The goal is to create a resource for researchers to discover new biomarkers and develop better treatments. Participants will not rece…

This study aims to create a collection of blood and urine samples from 350 children with bone, calcium, or growth plate disorders. Researchers will use these samples to learn more about how these diseases progress and to identify new targets for treatment. The study does not test…

This study looks at whether inflammation inside the heart plays a role in arrhythmogenic right ventricular cardiomyopathy (ARVC), a rare heart condition. Researchers will measure inflammatory markers in the blood of 80 participants, including people with ARVC and healthy controls…

This study looks at pain in people with idiopathic REM sleep behavior disorder (iRBD), a condition that strongly increases the risk of developing Parkinson's disease. Researchers will compare pain levels and patterns between 24 participants with iRBD and a control group with narc…

This study looks at heart valve tissue from 100 adults having surgery for narrowed aortic valves. Researchers want to find out how often a specific protein called ATTR amyloid builds up in the valve. This is an observational study, not a treatment, and aims to better understand t…

This study uses small motion sensors to detect internal tremors—a common but hard-to-measure symptom—in people with Parkinson's disease. Researchers will compare 60 participants (30 with Parkinson's and 30 healthy volunteers) to see if a specific 4-6 Hz rhythm can be identified. …

This study is testing whether a special PET scan can detect inflammation in the brains of people with autoimmune encephalitis (AE), a condition where the immune system attacks the brain. Researchers will compare scan results from 40 AE patients to those from healthy volunteers. T…

This study aims to collect blood and urine samples from 100 children and adults with Noonan syndrome to create a biological collection for research. The goal is to better understand the disease and find factors that predict how it progresses. Participants provide extra samples du…

This study looks at people with epilepsy that doesn't get better with medication. These patients already need brain electrodes to find where seizures start. Researchers want to see if using a wider range of electrical stimulation frequencies can better pinpoint the seizure zone a…