New DNA test could spot lung cancer in tiny nodules
NCT ID NCT05306912
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study aims to see if analyzing DNA from fluid left over after a lung nodule biopsy can better detect cancer. About 60 adults with small lung nodules (20 mm or less) will have a standard bronchoscopy, and the leftover fluid will be tested for cancer-related DNA changes. If successful, this approach could improve diagnosis without extra procedures.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 60 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Apr 2022
- Expected to finish
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Dec 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * rEBUS bronchoscopy planned for one, two or three ≤ 20 mm nodule * World Health Organization (WHO) Performance status 0-3 * Informed signed consent * Patient affiliated or beneficiary of a social security scheme (Social Security or Universal Medical Coverage). Exclusion Criteria: * Lung cancer diagnosed before the date of the procedure * Lung cancer strongly suspected due to mediastinal or extra thoracic lesions * Patient under State Medical Assistance * Patient deprived of liberty on administrative or judicial decision, or patient under guardianship, curators or safeguard of justice
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Toulouse University Hospital
RECRUITINGToulouse, Occitanie, 31300, France
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