University Hospital, Toulouse

This study tests whether adding avacopan to standard treatment helps people with severe ANCA vasculitis—a rare autoimmune disease that attacks the kidneys. About 130 adults with very low kidney function will receive either avacopan or a placebo alongside usual drugs. The goal is …

This study tests whether rapamycin is safe for teenagers aged 12 to 17 with familial adenomatous polyposis (FAP), a condition that causes many polyps in the colon. Researchers will give two low doses of rapamycin and watch for side effects. They will also check if the drug reduce…

This study tests whether treating children with uncomplicated appendicitis using antibiotics alone works as well as surgery. About 724 children aged 5 to 15 will be randomly assigned to receive either antibiotics or an operation. The goal is to see if the antibiotic approach lead…

This early-stage trial is testing whether stem cells taken from donated fat tissue are safe when given through an IV to people with mild to moderate Alzheimer's disease. Nine participants will receive increasing doses of the cells and be monitored for side effects over six months…

This study tests whether an artificial intelligence (AI) program that gives personalized diet and exercise advice can help people with non-alcoholic fatty liver disease (NAFLD) reduce liver fat more than standard lifestyle counseling. About 216 adults with NAFLD and overweight wi…

This study looks at whether simple eye-tracking tests and MRI brain scans can detect very early signs of Alzheimer's disease in healthy older adults. Researchers will study 100 people (half with a genetic risk factor called APOE4) to see if changes in the brain's 'locus coeruleus…

This study aims to see if a special MRI scan can accurately diagnose invasive upper urinary tract tumors. About 178 adults with suspicious findings on a CT scan will receive an MRI, and the results will be compared to standard biopsy or follow-up CT. If successful, MRI could offe…

This study looks at whether eating only during early hours and exercising in the afternoon can prevent muscle loss (sarcopenia) in postmenopausal women who have obesity and type 2 diabetes. About 45 women will follow a 12-week program combining early time-restricted eating with e…

This pilot study tests whether two ketamine infusions can quickly reduce symptoms in people with severe borderline personality disorder (BPD). Thirty-eight adults will receive the infusions along with standard psychiatric care and be followed for three months. The goal is to see …

This study tests whether injecting botulinum toxin (Botox) into the hands or feet can help people with Buerger's disease, a rare condition that blocks blood flow and causes severe pain. Eight adults with critical limb ischemia will receive a single injection session and be follow…

This study tests if a TENS device, which sends mild electrical pulses through the skin, can reduce pain during a common back injection procedure. About 52 adults with chronic low back pain will receive either a real TENS or a fake one during their injection. The goal is to see if…

This study looks at whether medical hypnosis or virtual reality can reduce anxiety in adults with acute myeloid leukemia during their first round of chemotherapy. About 99 participants will be split into three groups: standard care alone, standard care plus hypnosis, or standard …

This study tests a new care pathway for people with epilepsy who are starting or switching anti-seizure medications. For six months, participants will receive remote monitoring and support from a nurse to help them stay on track with their medication and catch side effects or sei…

This study tests whether clinical hypnosis and self-hypnosis can improve quality of life and reduce hot flashes in menopausal women who cannot or choose not to use hormone therapy. About 94 women will be randomly assigned to hypnosis or a supportive conversation group. The main g…

This study explores whether intensive rhythm-based music training can improve attention, planning, and reading in children aged 8 to 10 with complex neurodevelopmental disorders (like ADHD combined with dyslexia). Six children will take part in a structured program, and researche…

This study tests whether injections of donor stem cells around the mouth can reduce fibrosis and improve daily function in 50 adults with systemic scleroderma who have limited mouth opening. Participants will receive either stem cells or a placebo, and researchers will measure ch…

This study tests a program called Hear2Share that helps elderly nursing home residents with hearing loss communicate better. About 40 participants will use a simple hearing device guided by staff. The goal is to see if it improves word recognition and reduces feelings of isolatio…

This study looks at whether a new observation grid can help doctors and therapists consistently identify early signs of developmental problems in very premature babies (born at 27-32 weeks). Researchers will film 35 infants at home and have different professionals use the grid to…

This study looks at whether cannabis byproducts can be found in the sweat of young children (3 months to 3 years) who come to the emergency room with acute cannabis poisoning. Researchers want to know if sweat contamination might affect hair tests used to check for past exposure.…

This study looks at how the brain reorganizes itself after hearing loss and a cochlear implant. Researchers will use EEG and eye-tracking to measure attention and brain waves in 90 adults. The goal is to find patterns that predict how well someone will recover their hearing.

This study looks at how well platelets work in patients on a life-support machine called ECMO, which helps people with severe lung or heart problems. The goal is to understand why these patients often have dangerous bleeding. Researchers will measure platelet function over time a…

This study tests two artificial intelligence (AI) models that aim to predict how Parkinson's disease will progress and whether medication will cause side effects. Researchers will collect information from 100 people with Parkinson's, including data from a smartwatch and a mobile …

This study tests a flexible, home-based care pathway for people just diagnosed with Parkinson's disease (within the last month) and their caregivers. The program includes a booklet and website to help patients and families understand the disease and connect with local support. Th…

This study looks at obese adults who use a CPAP machine for sleep apnea to see if they still have dangerously low breathing at night. Researchers will use a special skin sensor to measure carbon dioxide levels while participants sleep. The goal is to find out how common this hidd…

This study aims to translate and adapt an English scale (EmNSA) into French to better assess sensation in the legs of adults with acquired brain injury. Researchers will test the new French version on 50 patients to ensure it is accurate and reliable. The goal is to provide a val…

This study looks at 117 people who had a brain bleed (intracerebral hemorrhage) to understand how inflammation and damage to the brain's protective barrier affect recovery. Participants will get special brain scans and blood tests about 10 days after the bleed. The goal is to lin…

This study looks at how different parts of the brain handle thinking skills like memory, language, and perception. Researchers will test 120 people with brain tumors before and during awake surgery to see which brain areas are active. The goal is to create a detailed map of the b…

This study looks at how well adults aged 65 and older recover after neurosurgery, focusing on their ability to do daily activities. Researchers in France, Spain, and Portugal will follow 209 patients for 3 months after they leave the hospital. The goal is to understand what helps…

This study aims to see if a portable, low-field MRI can detect brain damage in coma patients after cardiac arrest as well as standard high-field MRI does. Researchers will scan 60 participants (30 coma patients and 30 healthy volunteers) multiple times over two weeks. The goal is…

This study looks at how men and women with Fabry disease are diagnosed and treated. Fabry disease affects men and women differently, and women are often diagnosed later or through family screening. Researchers will survey 200 adults with Fabry disease to compare their care paths …