New drug combo aims to save kidneys in rare autoimmune disease
NCT ID NCT07373262
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This Phase 3 trial tests whether adding avacopan to standard treatment helps people with severe ANCA vasculitis and serious kidney damage. About 130 participants will receive either avacopan or a placebo alongside usual care. The goal is to see if more patients recover kidney function and need fewer steroids.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Avacopan
What this could lead to
If successful, adding avacopan to standard therapy could improve kidney recovery and reduce the need for high-dose steroids in severe ANCA vasculitis.
What could go wrong
This is a Phase 3 trial, but it's still early for this specific severe group. Avacopan may not improve outcomes enough, and side effects or infections remain possible.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
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Contact
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Locations
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Amiens Hospital
Amiens, France
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Angers Hospital
Angers, France
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Besançon Hospital
Besançon, France
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Bichat Hospital
Paris, France
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Bordeaux Hospital
Bordeaux, France
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Boulogne-sur-Mer Hospital
Boulogne-sur-Mer, France
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Brest Hospital
Brest, France
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Caen Hospital
Caen, France
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Cochin Hospital
Paris, France
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George Pompidou Hospital
Paris, France
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Grenoble Hospital
Grenoble, France
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Henri Mondor Hospital
Paris, France
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Kremlin Bicêtre Hospital
Paris, France
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Le Mans Hospital
Le Mans, France
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Lille Hospital
Lille, France
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Limoges Hospital
Limoges, France
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Marseille Hospital
Marseille, France
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NANCY Hospital
Vandœuvre-lès-Nancy, France
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Nantes Hospital
Nantes, France
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Necker Hospital
Paris, France
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Nimes Hospital
Nîmes, France
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ROuen Hospital
Rouen, France
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Reims Hospital
Reims, France
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Saint exupery hospital
Toulouse, France
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Strasbourg Hospital
Strasbourg, France
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Tenon Hospital
Paris, France
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Toulouse Hospital
Toulouse, France
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Tours Hospital
Tours, France
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Valenciennes Hospital
Valenciennes, France
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Vendée Hospital
La Roche-sur-Yon, France
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