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New drug combo aims to save kidneys in rare autoimmune disease

NCT ID NCT07373262

Not yet recruiting Disease control Sponsor: University Hospital, Toulouse Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 3 trial tests whether adding avacopan to standard treatment helps people with severe ANCA vasculitis and serious kidney damage. About 130 participants will receive either avacopan or a placebo alongside usual care. The goal is to see if more patients recover kidney function and need fewer steroids.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Avacopan
What this could lead to
If successful, adding avacopan to standard therapy could improve kidney recovery and reduce the need for high-dose steroids in severe ANCA vasculitis.
What could go wrong
This is a Phase 3 trial, but it's still early for this specific severe group. Avacopan may not improve outcomes enough, and side effects or infections remain possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

anti-neutrophil cytoplasmic antibody-associated vasculitis granulomatosis with polyangiitis rapidly progressive glomerulonephritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANCA ASSOCIATED VASCULITIS (AAV)

Contacts and locations

Locations

  • Amiens Hospital

    Amiens, France

  • Angers Hospital

    Angers, France

  • Besançon Hospital

    Besançon, France

  • Bichat Hospital

    Paris, France

  • Bordeaux Hospital

    Bordeaux, France

  • Boulogne-sur-Mer Hospital

    Boulogne-sur-Mer, France

  • Brest Hospital

    Brest, France

  • Caen Hospital

    Caen, France

  • Cochin Hospital

    Paris, France

  • George Pompidou Hospital

    Paris, France

  • Grenoble Hospital

    Grenoble, France

  • Henri Mondor Hospital

    Paris, France

  • Kremlin Bicêtre Hospital

    Paris, France

  • Le Mans Hospital

    Le Mans, France

  • Lille Hospital

    Lille, France

  • Limoges Hospital

    Limoges, France

  • Marseille Hospital

    Marseille, France

  • NANCY Hospital

    Vandœuvre-lès-Nancy, France

  • Nantes Hospital

    Nantes, France

  • Necker Hospital

    Paris, France

  • Nimes Hospital

    Nîmes, France

  • ROuen Hospital

    Rouen, France

  • Reims Hospital

    Reims, France

  • Saint exupery hospital

    Toulouse, France

  • Strasbourg Hospital

    Strasbourg, France

  • Tenon Hospital

    Paris, France

  • Toulouse Hospital

    Toulouse, France

  • Tours Hospital

    Tours, France

  • Valenciennes Hospital

    Valenciennes, France

  • Vendée Hospital

    La Roche-sur-Yon, France

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