Fat stem cells injected into face could ease scleroderma mouth stiffness

NCT ID NCT07326033

Not yet recruiting Symptom relief Sponsor: University Hospital, Toulouse Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether injections of stem cells from donated fat tissue can help loosen mouth fibrosis in people with systemic scleroderma. Fifty adults with limited mouth opening will receive either stem cell or placebo injections around the mouth and be followed for 24 weeks. The main goal is to see if the treatment improves mouth function and quality of life.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: allogeneic cultured adipose-derived mesenchymal stromal cells (AdMSC)
What this could lead to: If it works, this could offer a new way to reduce mouth tightness and improve eating, speaking, and oral care for people with scleroderma.
What could go wrong: This is an early phase 2 trial with only 50 participants, so results may not apply to everyone. The treatment involves injections and could cause side effects like pain or swelling.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Microstomia systemic sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SYSTEMIC SCLERODERMA

Contacts and locations

Locations

Bordeaux Hospital

Bordeaux, France
Dijon Hospital

Dijon, France
Montpellier Hospital

Montpellier, France
Nantes Hospital

Nantes, France
Toulouse Hospital

Toulouse, France

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