Could a common drug curb polyps in teens with rare genetic condition?
NCT ID NCT06308445
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study tests two low doses of rapamycin, a drug usually used to prevent organ rejection, in 25 teenagers (ages 12-17) with familial adenomatous polyposis (FAP), a genetic condition that causes many colon polyps and raises cancer risk. The main goal is to see if the drug is safe and tolerable. Researchers will also check if it reduces the number or size of polyps. The study is not yet recruiting.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Rapamycin
- What this could lead to
- If successful, this could point toward a way to slow or reduce polyp growth in teens with FAP, potentially delaying or avoiding surgery.
- What could go wrong
- This is a small, early safety study (Phase 2) with only 25 participants. Rapamycin has known side effects, and it is not yet proven to work for FAP. The results may not apply to all patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Email: •••••@•••••
Locations
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APHP Hôpital Robert Debré
Paris, 75019, France
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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CHU Bordeaux Hôpital Pellegrin
Bordeaux, 33076, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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CHU Montpellier Hôpital Arnaud de Villeneuve
Montpellier, 34295, France
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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CHU Toulouse Hôpital des Enfants
Toulouse, 31300, France
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Other studies related to the condition(s) this trial covers.
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- Tailored scope schedule may cut cancer risk in FAP patients