Shunt surgery may reverse liver failure in some cirrhosis patients

NCT ID NCT07172035

Recruiting now Disease control Sponsor: Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether a procedure called TIPS, which creates a bypass in the liver, can help people with advanced cirrhosis achieve 'recompensation' — meaning the liver partially recovers and complications ease. Researchers will follow 250 patients for one year after TIPS to see how many meet recompensation criteria and what factors influence success. The goal is to improve survival and reduce the need for liver transplants.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Transjugular intrahepatic portosystemic shunt (TIPS) procedure
What this could lead to: If successful, this could show that TIPS helps some patients with advanced cirrhosis achieve liver recompensation, potentially reducing complications and improving survival.
What could go wrong: This is an early-stage observational study, not a randomized trial, so results may not prove cause and effect. TIPS also carries risks like liver function decline and brain fog (hepatic encephalopathy).

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Conditions

The condition(s) this trial relates to.

chronic liver failure cirrhosis of liver Fibrosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CIRRHOSIS DECOMPENSATION SURVIVAL ANALYSIS TRANSJUGULAR INTRAHEPATIC PORTOSYSTEMIC SHUNT (TIPS)

Contacts and locations

Locations

Fujian Medical University Union Hospital
RECRUITING

Fuzhou, China
Huanggang Central Hospital
RECRUITING

Huanggang, China
Jiangxi Provincial People's Hospital
RECRUITING

Nanchang, China
Jingzhou Central Hospital
RECRUITING

Jingzhou, China
Renmin Hospital of Wuhan University
RECRUITING

Wuhan, China
Second Xiangya Hospital, Central South University
RECRUITING

Changsha, China
Shanxi Provincial People's Hospital
RECRUITING

Taiyuan, China
Shengjing Hospital of China Medical University
RECRUITING

Shenyang, China
The First Affiliated Hospital of Nanjing Medical University
RECRUITING

Nanjing, China
The First Affiliated Hospital of Zhengzhou University
RECRUITING

Zhengzhou, China
The Third Xiangya Hospital of Central South University
RECRUITING

Changsha, China
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
RECRUITING

Wuhan, China
Xiangyang Central Hospital
RECRUITING

Xiangyang, China
Yichang Central People's Hospital
RECRUITING

Yichang, China
Zhongnan Hospital of Wuhan University
RECRUITING

Wuhan, China

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