1,200-Patient study aims to predict liver failure risks

NCT ID NCT05740358

Ongoing Knowledge-focused Sponsor: Northwestern University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This observational study follows 1,222 adults with liver cirrhosis to understand why some develop serious complications like fluid buildup or bleeding. Participants have check-ups every six months, including questionnaires, physical exams, and imaging. The goal is to build better prediction models to help doctors intervene earlier.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could help doctors predict which cirrhosis patients are at risk for serious complications, leading to earlier interventions.
What could go wrong: This is an observational study, not a treatment trial. It may not identify clear risk factors, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

alcoholic liver cirrhosis autoimmune hepatitis cirrhosis of liver Cirrhosis, Cryptogenic cirrhosis, familial Fibrosis hepatitis C induced liver cirrhosis metabolic dysfunction-associated steatotic liver disease primary biliary cholangitis primary sclerosing cholangitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AUTOIMMUNE HEPATITIS CIRRHOSIS CIRRHOSIS ADVANCED CIRRHOSIS ALCOHOLIC CIRRHOSIS CRYPTOGENIC CIRRHOSIS DUE TO HEPATITIS B CIRRHOSIS DUE TO HEPATITIS C CIRRHOSIS DUE TO PRIMARY SCLEROSING CHOLANGITIS CIRRHOSIS EARLY CIRRHOSIS INFECTIOUS CIRRHOSIS, BILIARY CIRRHOSIS, LIVER

Contacts and locations

Locations

Central Virginia Veterans Healthcare System

Richmond, Virginia, 23249, United States
Cleveland Clinic

Cleveland, Ohio, 44192, United States
Columbia University Iriving School of Medicine

New York, New York, 10031, United States
Duke Liver Center

Durham, North Carolina, 27710, United States
Keck Medical Center of USC

Los Angeles, California, 90033, United States
LAC + USC Medical Center

Los Angeles, California, 90033, United States
Mayo Clinic

Rochester, Minnesota, 55901, United States
New York Presbyterian/Weill Cornell

New York, New York, 10021, United States
UCSF Medical Center

San Francisco, California, 94143, United States
UCSF/Zuckerberg San Francisco General Hospital and Trauma Center

San Francisco, California, 94110, United States
University of California San Diego NAFLD Research Center

La Jolla, California, 92035, United States
University of Miami Health System

Miami, Florida, 33122, United States
University of Michigan

Ann Arbor, Michigan, 48109, United States
Virginia Commonwealth University

Richmond, Virginia, 23298, United States

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