500,000-Patient study aims to unlock secrets of chronic liver disease

NCT ID NCT05744713

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This observational study will follow up to 500,000 adults with chronic liver disease or cirrhosis to understand how the disease progresses and how treatments are used in everyday practice. Researchers will collect data from medical records and patient reports to improve care and outcomes. No new treatments are being tested; instead, the goal is to gather real-world evidence to guide future care.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to
If successful, this study could provide valuable insights into how chronic liver disease progresses and how current treatments work in real-world settings.
What could go wrong
This is an observational study, not a treatment trial, so it won't directly test new therapies. Results may take years and might not lead to immediate changes in care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Atrium Health Center for Liver Disease and Transplant

    Charlotte, North Carolina, 28204, United States

  • Baylor College of Medicine

    Houston, Texas, 77021, United States

  • Baylor Scott & White Research Institute

    Dallas, Texas, 75246, United States

  • Columbia University Irving Medical Center/ New York Presbyterian Hospital

    New York, New York, 10032, United States

  • Georgetown Medstar Transplant Institute

    Washington D.C., District of Columbia, 20007, United States

  • Keck School of Medicine of USC

    Los Angeles, California, 90033, United States

  • Rush University Medical Center

    Chicago, Illinois, 60612, United States

  • Stanford Medicine

    Redwood City, California, 94063, United States

  • Temple University - Lewis Katz School of Medicine

    Philadelphia, Pennsylvania, 19140, United States

  • University of Pennsylvania

    Philadelphia, Pennsylvania, 19104, United States

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