HEPATIC ENCEPHALOPATHY

This study tests two immune-suppressing medicines—high-dose steroids or a horse-derived antibody—in children with sudden, severe liver failure. The goal is to see if calming the immune system helps the liver heal so children can survive without needing a liver transplant. About 1…

This study tests whether adding the blood thinner apixaban to the standard drug carvedilol can prevent serious complications like bleeding, fluid buildup, and liver failure in people with cirrhosis and high blood pressure in the liver. About 220 adults with stable cirrhosis will …

This study tests whether taking a protein supplement (Ensure Enlive) in the late evening and early morning can reduce hospital readmissions for people with hepatic encephalopathy, a condition causing confusion due to liver disease. About 40 adults with cirrhosis and a recent hosp…

This study tests a dietary supplement made from resistant potato starch in 11 people with cirrhosis and a history of hepatic encephalopathy (brain fog). The goal is to see if the starch changes gut bacteria and improves thinking. Participants take the supplement for 4 weeks and p…

This study tests whether giving a protein called albumin through a vein can improve thinking and memory in people with cirrhosis who have had episodes of hepatic encephalopathy (brain fog). Thirty adults with cirrhosis and mild cognitive problems will receive both albumin and a s…

This study aims to create and test a new questionnaire called LiCCoS for adults with liver cirrhosis. The goal is to help identify common thinking problems like forgetfulness and trouble focusing, which are often missed in regular checkups. About 230 participants will fill out th…

This study follows 10,000 adults with advanced chronic liver disease to see how their health changes over time. Researchers will collect medical data and samples like blood, urine, and tissue to better understand cirrhosis and its complications. Participants receive regular check…