LIVER CIRRHOSIS

This study is testing a device called DIALIVE 2.0, which works like dialysis for the liver. It aims to help people with sudden, severe liver failure on top of long-term liver disease by filtering toxins from their blood and replacing a key protein. The trial will compare the devi…

This study is testing a new combination treatment for people with advanced liver cancer (hepatocellular carcinoma) who also have high blood pressure in their liver (portal hypertension) due to cirrhosis. The treatment combines a minimally invasive procedure (TACE) with three drug…

This small study is testing whether a patient's own bone marrow cells, combined with growth-promoting substances, can help improve liver function in people with cirrhosis (scarring of the liver). Doctors will take a small sample of bone marrow from the patient, process it, and gi…

This study aims to see if adding a blood pressure medication called midodrine to a standard liver drug (carvedilol) works better than carvedilol alone to prevent a second, dangerous bleeding episode in people with advanced liver cirrhosis. It will enroll 210 patients in India who…

This study aims to settle a medical debate about whether patients with advanced liver disease (cirrhosis) should routinely take acid-suppression drugs after a preventive procedure for swollen veins in their esophagus. Researchers will enroll 210 patients and randomly assign half …

This study compares two different medical procedures for people with advanced liver disease who experience dangerous bleeding from swollen veins in their stomach and esophagus. Researchers will follow 140 patients to see whether surgery to remove the spleen and reroute blood flow…

This study aims to find out which of two existing drugs works better for liver cirrhosis patients who have a dangerous stomach bleed and sudden kidney injury. Researchers will compare terlipressin and somatostatin in 64 patients to see which one is more effective at reversing the…

This early-stage trial will test whether tiny particles from umbilical cord stem cells are safe for people with liver cirrhosis. Twelve adults with moderate liver scarring will receive increasing doses through an IV to check for side effects. Researchers will also look for early …

This study aims to see if a special type of ultrasound can be used to diagnose a rare liver condition called porto-sinusoidal vascular disorder (PSVD) without needing a surgical biopsy. Researchers will compare the ultrasound results from 100 people who have PSVD to those who hav…

This study aims to see if a new blood test score, called GAAD, can help doctors find liver cancer earlier in people at high risk. It will enroll 2,100 adults with chronic liver disease or cirrhosis. Participants will get standard ultrasound checks plus the GAAD score test every s…

This study is testing a new, non-invasive ultrasound method to find dangerous swollen veins in the stomach and esophagus of people with liver cirrhosis. Researchers want to see if this scan, combined with a liver stiffness test and a blood platelet count, can accurately identify …

This study is testing whether a combination of electrical muscle stimulation and resistance exercises can help hospitalized patients with alcoholic liver cirrhosis who have lost muscle mass (sarcopenia). The goal is to see if this approach improves leg strength and physical perfo…

This study aims to understand how many adults in India with liver cirrhosis are already protected against Hepatitis A virus (HAV). For those who are not protected, researchers will test how well a single dose of the Hepatitis A vaccine works and how long the protection lasts. The…

This study aims to see if using remote monitoring tools helps track the health of people with liver cirrhosis. It will follow 750 patients who are already receiving standard care at hospitals that have added remote monitoring. The researchers will collect medical data to understa…

This study aims to better understand a dangerous blood clot complication called portal vein thrombosis (PVT) in people with liver cirrhosis. It will follow about 2,500 patients over time to identify who is most at risk, measure how the clots affect health and survival, and compar…

This study aims to test and compare new scoring systems designed to predict complications and survival in hospitalized patients with advanced liver cirrhosis (liver scarring). Researchers will enroll 100 adults admitted to the hospital with a serious complication of their liver d…