LIVER CIRRHOSIS

This study tests a controlled blood removal method during liver surgery to see if it lowers the need for blood transfusions. About 60 adults having liver resection for cancer will take part. The approach involves removing a small amount of blood before surgery and giving it back …

This study tests whether the blood thinner rivaroxaban can safely improve outcomes in people with liver cirrhosis who have both a blood clot in the portal vein and a high risk of variceal bleeding. About 175 participants will receive rivaroxaban or standard care starting 48 hours…

This study compares two procedures for people with liver cirrhosis who have severe bleeding from enlarged veins in the esophagus and an enlarged spleen. One procedure removes the spleen and disconnects certain veins (LSD), while the other places a shunt inside the liver (TIPS). T…

This study compares a new procedure using a special stent (underdilated VCX-TIPS) with standard treatment (endoscopic banding plus beta-blockers) to prevent variceal rebleeding in people with cirrhosis. The new approach uses a smaller balloon to expand the stent, aiming to lower …

This study tests a new procedure that uses an endoscope (a thin tube with a camera) to guide coils and glue into abnormal blood vessels in the liver. The goal is to block these vessels and reduce severe confusion (hepatic encephalopathy) in people with liver cirrhosis. The trial …

This study tests a device called DIALIVE 2.0, which acts like a dialysis machine for the liver, in people with severe acute-on-chronic liver failure (ACLF). The goal is to see if adding up to 7 daily treatments to standard care helps more patients recover from liver failure and s…

This early-stage study tests whether tiny particles from umbilical cord stem cells, called extracellular vesicles, are safe for people with liver cirrhosis. Up to 12 adults with moderate to severe liver damage will receive increasing doses through an IV. The goal is to see if thi…

This study tests whether adding midodrine to the standard drug carvedilol can prevent early rebleeding in people with cirrhosis who have had a variceal bleed. About 210 high-risk patients will receive either carvedilol alone or carvedilol plus midodrine for 6 weeks. The goal is t…

This study tests a fiber-optic navigation system that gives doctors a 3D view during a procedure called TIPS, which treats complications of liver cirrhosis like fluid buildup or bleeding. About 30 patients will be enrolled to see if the device reduces the number of needle sticks,…

This early trial tests whether a patient's own bone marrow cells, mixed with growth factors, can help treat liver cirrhosis. Ten adults with cirrhosis (but no active cancer or severe infection) will receive the cells through an IV. The main goal is to see if the treatment improve…

This study tests a new combination of four treatments for people with liver cancer that cannot be removed by surgery and who also have high blood pressure in the liver (portal hypertension). The goal is to see if adding a blood-pressure drug (carvedilol) to standard cancer therap…

This study tests two blood products used to control bleeding during liver transplant surgery. It compares a newer product, Intercept Fibrinogen Complex, to standard cryoprecipitate. The goal is to see if the newer product works as well or better at stopping bleeding. The study wi…

This study compares two drugs, terlipressin and somatostatin, in 64 adults with liver cirrhosis who have acute gastrointestinal bleeding and acute kidney injury. Both drugs are given intravenously for up to 5 days. The main goal is to see which drug better reverses kidney injury.…

This study will test whether using a contrast agent called Sonazoid during ultrasound can find early-stage liver cancer better than standard ultrasound alone. About 556 adults with liver cirrhosis will be scanned every 4 to 6 months. The goal is to see if this method catches more…

This study explores whether a special ultrasound technique, called dynamic contrast-enhanced ultrasound (DCE-US), can diagnose porto-sinusoidal vascular disorder (PSVD) without needing a liver biopsy. Researchers will compare ultrasound images from 100 people with PSVD or cirrhos…

This study tests whether taking a low-dose aspirin (100 mg) every day can prevent liver cancer in people with cirrhosis, a condition that raises cancer risk. About 890 adults from Australian hospitals will take aspirin or a placebo for 4 years while continuing their regular check…

This study tests whether adding neuromuscular electrical stimulation (NMES) to resistance exercises can improve muscle strength and physical performance in hospitalized patients with alcoholic liver cirrhosis who have muscle loss (sarcopenia). About 112 participants aged 47–70 wi…

This study explores whether a non-invasive test called the vascular occlusion test (VOT), used with near-infrared spectroscopy, can predict early allograft dysfunction (EAD) in adults receiving a liver transplant. EAD is a serious complication that can lead to organ failure. Rese…

This study looks at hepatic encephalopathy, a brain complication from liver cirrhosis that can cause memory loss and confusion. Researchers will follow over 700 liver cirrhosis patients and 120 healthy volunteers in China for up to 3 years. Participants use a simple phone app to …

This study looks at whether a simple, non-invasive ultrasound can predict the risk of dangerous bleeding from enlarged veins in the esophagus (varices) in people with liver cirrhosis. Researchers will measure spleen size and a key blood vessel diameter on ultrasound and compare t…

This study will check children under 18 with chronic liver disease for hidden heart problems. Doctors will use simple tests like ECG and ultrasound to look for issues such as abnormal heart rhythms or weakened heart muscle. The goal is to better understand how liver disease affec…

This study aims to create detailed computer models, or 'virtual twins,' of people with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). By analyzing data from over 7,700 adults, researchers hope to better understand how the disease progresses and predict who migh…

This study looks at how many adults with liver cirrhosis have natural protection against hepatitis A and how well a single vaccine dose works for those who are not protected. About 360 participants will be tested and followed. The goal is to provide better vaccination guidelines …

This study will follow about 2,500 adults with liver cirrhosis to learn who gets dangerous blood clots in the liver's main vein, how these clots affect survival, and whether blood-thinner medications are safe and helpful. Participants receive no experimental treatment—just routin…

This study will take small kidney tissue samples from 42 liver transplant patients who have hepatorenal syndrome (HRS), a condition where the kidneys stop working properly due to severe liver disease. Researchers want to see if the kidneys are actually damaged or just temporarily…

This study will test new scoring systems to see how well they predict serious complications and death in 100 adults hospitalized with liver cirrhosis. Researchers will compare these new scores to standard ones to find which best identifies high-risk patients. The goal is to impro…

This study follows 750 adults with liver cirrhosis to see how remote monitoring affects their care. Participants share medical data from home, but no new treatment is tested. The goal is to track complications like fluid buildup or liver failure and hospital visits over time.