LIVER CIRRHOSIS

This study tests whether adding midodrine to the standard drug carvedilol can prevent early rebleeding in people with liver cirrhosis who have had a variceal bleed. About 210 adults with moderate to severe cirrhosis will be randomly assigned to receive either both drugs or carved…

This study tests a new procedure using an endoscope to block abnormal blood vessels in the liver that can cause severe confusion (hepatic encephalopathy) in people with cirrhosis. About 34 adults who have not gotten better with standard medicines will either receive the procedure…

This study tests a new combination of four treatments for people with liver cancer that cannot be removed by surgery and who also have high blood pressure in the liver (portal hypertension). The goal is to see if adding a blood pressure drug (carvedilol) to standard cancer therap…

This early-phase study tests the safety of a new treatment for liver cirrhosis. The therapy uses tiny particles (extracellular vesicles) from umbilical cord stem cells, given through a vein. Up to 12 adults with moderate-to-severe liver damage will receive increasing doses to see…

This study tests a device called DIALIVE 2.0, which acts like a dialysis machine for the liver, in people with acute-on-chronic liver failure (ACLF) grades 2-4. About 72 adults aged 18-70 with liver cirrhosis and recent worsening will either receive standard care or standard care…

This study compares two medications, terlipressin and somatostatin, in 64 adults with liver cirrhosis who have both acute gastrointestinal bleeding and acute kidney injury. The goal is to see which drug better reverses the kidney damage. Participants will be randomly assigned to …

This study compares two treatments for people with liver cirrhosis who have severe bleeding from enlarged veins in the stomach or esophagus and an overactive spleen. One treatment is a surgery to remove the spleen and disconnect certain veins, and the other is a less invasive pro…

This early study tests a new treatment for liver cirrhosis using a patient's own bone marrow cells mixed with growth factors. Ten adults with cirrhosis (any stage) who are under 80 and free of active cancer or severe infection will receive the cells by IV. The goal is to see if t…

This study looks at whether a special ultrasound using a contrast agent called Sonazoid can find early-stage liver cancer better than a regular ultrasound. About 556 adults with liver cirrhosis will be monitored every 4 to 6 months with both methods. The goal is to see if Sonazoi…

This study explores whether a special ultrasound technique (dynamic contrast-enhanced ultrasound) can accurately diagnose a rare liver condition called porto-sinusoidal vascular disorder (PSVD) without needing an invasive liver biopsy. Researchers will compare ultrasound results …

This study tests whether taking a low-dose aspirin (100 mg) every day can prevent liver cancer in people with cirrhosis, a condition that raises cancer risk. About 890 adults from Australian hospitals will take either aspirin or a dummy pill for 4 years while continuing their usu…

This study tests whether adding neuromuscular electrical stimulation to resistance exercises can improve leg strength and physical function in hospitalized adults (ages 47-70) with alcoholic liver cirrhosis and muscle wasting (sarcopenia). Participants will be randomly assigned t…

This study looks at how many adults with cirrhosis have natural protection against hepatitis A and how well a single dose of the vaccine works for those who are not immune. Researchers will test blood samples from 360 participants in India. The goal is to provide better guidance …

This study will test new scoring methods to predict complications and death risk in 100 adults hospitalized with liver cirrhosis. Researchers will compare these new scores to standard ones to see which are more accurate. The goal is to help doctors identify high-risk patients ear…

This study will follow about 2,500 adults with liver cirrhosis to learn why some develop a dangerous blood clot in the liver's main vein (portal vein thrombosis). Researchers will review past cases and track new patients for two years to build a prediction tool, measure how the c…

This study tests a new fiber-optic navigation system during a procedure called TIPS, which treats complications of liver cirrhosis like fluid buildup or bleeding. About 30 adults needing this procedure will be enrolled. The goal is to see if the technology helps doctors complete …

This study looks at children under 18 with chronic liver disease to see if they have hidden heart problems. Doctors will use simple tests like blood work, ultrasound, and heart scans to check for conditions such as portopulmonary hypertension and cirrhotic cardiomyopathy. The goa…

This study follows 750 adults with liver cirrhosis to see how the disease progresses when hospitals use remote monitoring as part of standard care. Participants share their medical records and home-monitoring data, but there is no new treatment or intervention. The goal is to lea…