Liver cirrhosis bleeding: which procedure wins?
NCT ID NCT07490405
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study compares two procedures for people with liver cirrhosis who have severe bleeding from enlarged veins in the esophagus and an enlarged spleen. One procedure removes the spleen and disconnects certain veins (LSD), while the other places a shunt inside the liver (TIPS). The main goal is to see which procedure causes fewer brain complications. The trial will follow 140 participants for long-term outcomes like survival and re-bleeding.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- laparoscopic splenectomy and azygoportal disconnection (LSD) or transjugular intrahepatic portosystemic shunt (TIPS)
- What this could lead to
- If this trial succeeds, it could show which procedure is safer and more effective for controlling bleeding and preventing brain complications in people with liver cirrhosis.
- What could go wrong
- This is a single-center trial with only 140 participants, so results may not apply to everyone. Both procedures carry risks like infection, bleeding, or liver problems.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Northern Jiangsu People's Hospital
Yangzhou, Jiangsu, 225000, China
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