Could a simple ultrasound replace liver biopsies for this rare disease?

NCT ID NCT07492862

Not yet recruiting Diagnosis Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study explores whether a special ultrasound technique, called dynamic contrast-enhanced ultrasound (DCE-US), can diagnose porto-sinusoidal vascular disorder (PSVD) without needing a liver biopsy. Researchers will compare ultrasound images from 100 people with PSVD or cirrhosis to see if blood flow patterns differ. If it works, this painless test could make diagnosis easier and faster.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: contrast-enhanced ultrasound with VueBox software
What this could lead to: If successful, this could provide a noninvasive way to diagnose PSVD, avoiding the need for a liver biopsy.
What could go wrong: This is an early exploratory study with only 100 participants, so results may not be conclusive or widely applicable. The technique may not reliably distinguish PSVD from cirrhosis.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cirrhosis of liver portal hypertension portal hypertension, noncirrhotic portosinusoidal vascular disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CONTRAST ENHANCED ULTRASOUND LIVER CIRRHOSIS PORTAL HYPERTENSION RELATED TO CIRRHOSIS PORTAL HYPERTENSION, NONCIRRHOTIC PORTO-SINUSOIDAL VASCULAR LIVER DISORDER ULTRASOUND ELASTOGRAPHY

Contacts and locations

Locations

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Roma, RM, 00168, Italy

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