LIVER CIRRHOSIS

This study is testing if using a slightly narrower stent during a common liver procedure can reduce a serious side effect called hepatic encephalopathy (brain fog) without increasing the risk of bleeding again. It will involve 170 adults with cirrhosis who have had severe bleedin…

This study aims to improve safety for patients receiving a liver transplant from a living donor. Researchers will follow 30 adults with advanced liver cirrhosis to identify factors that predict dangerous blood clots or serious bleeding after surgery. The goal is to develop better…

This study is testing if using a special blood test (thrombelastography or TEG) to check and correct clotting problems before a liver shunt procedure is safe and works better than standard tests. It involves 39 adults with liver cirrhosis who need the shunt placed. The goal is to…

This study aims to find out if liver transplants are a good option for patients with a severe, sudden worsening of their chronic liver disease, known as ACLF. It will compare survival rates and quality of life for 3,000 very sick patients who get a transplant to those who do not.…

This study is testing whether a natural protein from spirulina algae, called phycocyanin, can help treat liver scarring (fibrosis and cirrhosis). Researchers will give the supplement or a placebo to 10 adult patients for at least 4 weeks to see if it reduces liver stiffness and l…

This study is testing if a high-flow nasal oxygen device is better than a standard one at preventing dangerously low oxygen levels in critically ill patients during sedated endoscopy. It will involve 450 patients with serious health conditions like liver cirrhosis. The goal is to…

This study is testing a new medicine, BI 3802876, for adults with advanced liver scarring (cirrhosis) caused by a type of fatty liver disease called MASH. The main goal is to see how safe the medicine is and how the body handles it. About 30 participants will be randomly assigned…

This study is testing a new way of placing a stent during a common liver procedure called TIPS. The goal is to see if starting with a smaller stent opening can reduce the risk of post-surgery brain complications (hepatic encephalopathy), which often cause confusion and memory pro…

This large trial is testing whether taking capsules containing processed stool from healthy donors can help people with advanced liver scarring (cirrhosis) avoid serious infections that lead to hospital stays. About 300 participants will take either the real capsules or placebo p…

This study is testing a new type of medical scan that combines two imaging techniques (PET and MRI) into one session. The goal is to see if this 'one-stop' scan can give doctors a clearer, more complete picture of liver damage, scarring (fibrosis), and cancer risk in people with …

This study is testing a new blood test algorithm called Elecsys GAAD to see if it can help detect liver cancer earlier in people with liver cirrhosis. Researchers will enroll 600 patients with cirrhosis to compare this new test against current standard screening methods. The main…

This large national trial aims to find the best method for early liver cancer detection in people at high risk. It will compare the current standard approach (an ultrasound plus a blood test) against a newer blood test alone. The goal is to see which method is more effective at f…

This study aims to understand why people with advanced liver disease (cirrhosis) are at risk for dangerous blood clots in a major abdominal vein. Researchers will enroll 45 patients who are already scheduled for a standard procedure to relieve liver pressure. During that procedur…

This study aims to find out if simple measurements like heart rate and blood pressure can help doctors predict how well liver cirrhosis patients will recover after a serious gastrointestinal bleed. Researchers will follow 150 patients to see if these common vital signs are reliab…

This study aims to understand if a person's handgrip strength is linked to blood flow and pressure in the liver's main vein (portal vein) in people with liver cirrhosis. Researchers will measure these pressures and blood flow in 120 participants before and after they perform a ma…

This study aims to understand if a liver transplant can stop or slow the hardening of arteries (calcification) in people with serious liver disease. Researchers will observe 95 patients who need a liver transplant, measuring artery health and a specific blood chemical before and …

This study aims to measure how well people with alcohol-related liver scarring understand health information and feel confident managing their condition. Researchers will survey 200 patients to gather this information. The goal is to learn about patients' needs to help design bet…

This study aims to better understand advanced liver cirrhosis by closely observing 10,000 patients over time. It collects detailed health information and optional biological samples to learn how the disease progresses and what affects patient survival. The goal is to gather knowl…

This early-stage study aims to understand how two common oral blood thinners (rivaroxaban and apixaban) are processed by the body in people with compensated liver cirrhosis. It will enroll 24 participants who will receive a single dose of one medication, followed by multiple bloo…

This study aims to understand how often people with liver cirrhosis see doctors and get medical scans, and what factors influence their healthcare use. Researchers will look back at the medical records of 600 adult patients with liver cirrhosis from multiple hospitals. The goal i…

This study aims to create and test a new questionnaire called LiCCoS, designed to help spot thinking and memory problems in adults with liver cirrhosis. Researchers will ask 230 participants with liver disease to complete the questionnaire and some standard memory tests to see if…