Engineered immune cells aim to calm liver scarring in first human trial

NCT ID NCT06823713

Recruiting now Disease control Sponsor: Resolution Therapeutics Limited Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new treatment called RTX001 for people with severe liver scarring (cirrhosis) that has led to complications. RTX001 uses the patient's own immune cells, modified in a lab to reduce inflammation and scarring. The trial will enroll 30 adults to check if the therapy is safe and can help control the disease.

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Conditions

The condition(s) this trial relates to.

alcoholic fatty liver disease chronic liver failure cirrhosis of liver End Stage Liver Disease fatty liver disease Fibrosis hepatic encephalopathy Jaundice liver disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CIRRHOSIS, DECOMPENSATED CIRRHOSIS, LIVER DECOMPENSATED CIRRHOSIS DECOMPENSATED LIVER CIRRHOSIS END-STAGE LIVER DISEASE (ESLD) FIBROSIS AND CIRRHOSIS OF LIVER LIVER DISEASES STEATOTIC LIVER DISEASE

Contacts and locations

Locations

Bristol Royal Infirmary
RECRUITING

Bristol, BS2 8HW, United Kingdom
Glasgow Royal Infirmary
RECRUITING

Glasgow, G4 0SF, United Kingdom
Hospital General Universitario Gregorio Marañon
RECRUITING

Madrid, 28007, Spain
Hospital Universitari Vall d'Hebron
RECRUITING

Barcelona, 08035, Spain
Hospital Universitario La Paz
RECRUITING

Madrid, 28046, Spain
Hospital Universitario Ramón y Cajal
RECRUITING

Madrid, 28034, Spain
Hospital Universitario Reina Sofía
RECRUITING

Córdoba, 14004, Spain
Hospital Universitario Virgen del Rocío
RECRUITING

Seville, 41013, Spain
King's College Hospital
RECRUITING

London, SE5 9RS, United Kingdom
Nottingham University Hospital
RECRUITING

Nottingham, NG5 1PB, United Kingdom
Royal Infirmary of Edinburgh
RECRUITING

Edinburgh, EH16 4SA, United Kingdom
Royal Liverpool University Hospital
RECRUITING

Liverpool, L7 8YE, United Kingdom
St George's Hospital
RECRUITING

London, SW17 0QT, United Kingdom
St Mary's Hospital
RECRUITING

London, W2 1NY, United Kingdom

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