DECOMPENSATED CIRRHOSIS

This study explores whether people with decompensated cirrhosis can receive acute medical care in their own homes instead of a hospital. Participants use remote monitoring devices, lab services, and virtual check-ins from a care team. The goal is to understand patient expectation…

This phase 3 trial tests whether fecal microbiota transplantation (FMT) — capsules containing processed stool from healthy donors — can slow the progression of decompensated cirrhosis, a severe form of liver disease. About 190 adults with advanced cirrhosis will receive either FM…

This trial tests whether using infection surveillance data to guide antibiotic selection can reduce antibiotic resistance in hospitalized cirrhosis patients with bacterial infections. About 198 adults with decompensated cirrhosis and a confirmed or suspected infection will be ran…

This study tests whether giving a higher dose of albumin (a protein) to people with advanced liver cirrhosis and fluid buildup (ascites) can reduce the need for fluid drainage procedures and prevent complications. About 100 adults with hard-to-treat ascites will receive either hi…

This study tests whether a home monitoring system called CirrhoCare can help people with decompensated cirrhosis avoid unplanned hospital visits. Participants use an Apple Watch, iPhone app, and Bluetooth devices to track their health at home. The trial will compare this approach…

This study tests a new treatment called RTX001 for people with severe liver scarring (cirrhosis) that has led to complications. RTX001 uses the patient's own immune cells, modified in a lab to reduce inflammation and scarring. The trial will enroll 30 adults to check if the thera…

This study looks at a heart condition called cirrhotic cardiomyopathy that can affect people with advanced liver disease (cirrhosis). Researchers want to learn how common it is, what increases the risk, and whether bile acids in the blood play a role. About 440 adults with decomp…