Precision radiotherapy targets rare breast tumors by genetic fingerprint

NCT ID NCT07657169

Not yet recruiting Disease control Sponsor: Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This trial investigates whether giving radiotherapy after surgery can prevent local recurrence in people with a rare breast tumor called phyllodes tumor, specifically those with high-risk molecular subtypes (MN1 or MN2). Participants who have had complete tumor removal will be randomly assigned to receive radiotherapy or just observation. The study aims to see if this personalized approach improves local control and safety.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Postoperative radiotherapy (radiation therapy)
What this could lead to: If successful, this could establish a precision radiotherapy approach for high-risk phyllodes tumors, reducing local recurrence and improving outcomes.
What could go wrong: This is a mid-stage trial with 160 participants, so results may not apply broadly. Radiotherapy carries risks of skin irritation, fatigue, and rare long-term side effects.

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Conditions

The condition(s) this trial relates to.

breast phyllodes tumor malignant breast phyllodes tumor phyllodes tumor

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MOLECULAR TYPING PHYLLODES BREAST TUMOR PROGNOSIS RADIOTHERAPY, ADJUVANT

Contacts and locations

Locations

Peking University Shenzhen Hospital

Shenzhen, Guangdong, 518000, China
Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University

Guangzhou, Guangdong, 510120, China
The Affiliated Hospital of Qingdao University

Qingdao, Shandong, 266003, China
The Second Hospital of Shandong University

Jinan, Shandong, 250033, China

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