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Supercharged immune cells take aim at childhood cancers

NCT ID NCT03635632

Ongoing Disease control Sponsor: Baylor College of Medicine Source: ClinicalTrials.gov ↗

First seen Jul 06, 2026 · Last updated Jul 07, 2026 · Updated 1 time

Summary

This study tests a new type of immunotherapy for people with cancers that have returned or not responded to treatment, such as neuroblastoma, sarcoma, and certain other solid tumors. The treatment uses a patient's own T cells, which are genetically modified to recognize a protein called GD2 on cancer cells and to produce a signal that helps them survive longer in the body. The goal is to find a safe dose and see whether these enhanced T cells can shrink tumors.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
C7R-GD2.CART cells (genetically modified T cells)
What this could lead to
If successful, this approach could provide a new treatment option for children and adults with hard-to-treat cancers that express GD2, potentially improving survival.
What could go wrong
This is an early phase 1 trial, so safety and effectiveness are not yet proven. The modified T cells may cause side effects like cytokine release syndrome or may not persist long enough to shrink tumors.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm Ewing sarcoma malignant breast phyllodes tumor neoplasm neuroblastoma osteosarcoma phyllodes tumor rhabdomyosarcoma sarcoma uveal melanoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PHYLLODES BREAST TUMOR REFRACTORY NEUROBLASTOMA RELAPSED EWING SARCOMA RELAPSED NEUROBLASTOMA RELAPSED OSTEOSARCOMA RELAPSED RHABDOMYOSARCOMA UVEAL MELANOMA

Contacts and locations

Locations

  • Houston Methodist Hospital

    Houston, Texas, 77030, United States

  • Texas Children's Hospital

    Houston, Texas, 77030, United States

More trials for these conditions

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