Can a common steroid gel quiet oral lichen planus by altering MicroRNAs?

NCT ID NCT05818618

Completed Disease control Sponsor: University of Catania Source: ClinicalTrials.gov ↗

First seen Aug 04, 2026 · Last updated Aug 12, 2026 · Updated 3 times

Summary

This trial investigates whether a topical clobetasol gel can change the levels of microRNAs in the gum fluid of people with oral lichen planus, a chronic inflammatory condition. Participants will apply either the active gel or a placebo to their lesions, and researchers will compare miRNA levels and symptom severity before and after treatment. The goal is to see if these molecular changes could serve as early indicators of disease activity or treatment response.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: clobetasol topical gel
What this could lead to: If clobetasol shifts miRNA levels, it could point toward a way to monitor or treat oral lichen planus more effectively.
What could go wrong: This is a small, early-stage trial, so results may not be conclusive. Clobetasol can cause local irritation or other side effects.

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Conditions

The condition(s) this trial relates to.

lichen planus, oral

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ORAL LICHEN PLANUS

Contacts and locations

Locations

AOU Policlinico G. Rodolico

Catania, Catania, 95124, Italy

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