Could a seed protein stop oral cancer? early study hints at promise

NCT ID NCT04188665

Completed Knowledge-focused Sponsor: Rowan University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase study looked at whether a protein from the Maackia amurensis seed (MASL) can target a receptor called podoplanin found on oral cancer and precancerous cells. Researchers measured how much of this receptor was present in tissue samples from 18 adults with suspicious mouth lesions. The goal was to see if MASL could reduce the receptor's activity and potentially slow cancer growth, but the study focused on understanding the biology rather than proving a treatment works.

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Conditions

The condition(s) this trial relates to.

erythroplakia head and neck squamous cell carcinoma leukoplakia lichen planus, oral oral cavity squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck squamous papilloma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SQUAMOUS CELL CARCINOMA OF HEAD AND NECK

Contacts and locations

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Locations

New Jersey Medical School

Newark, New Jersey, 07103, United States
Rowan University

Stratford, New Jersey, 08084, United States
Rutgers School for Dental Medicine

Newark, New Jersey, 07103, United States
University Hospital

Newark, New Jersey, 07103, United States