Can a vitamin d gel or light therapy stop precancerous mouth lesions?
NCT ID NCT07658508
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a vitamin D-based gel (calcipotriol) or a light-activated treatment (photodynamic therapy) can shrink or eliminate oral leukoplakia, a precancerous condition. Thirty adults with mild to moderate dysplasia will receive one of the two treatments for four weeks and be monitored for three months. Researchers will also check if the treatments reduce certain inflammatory markers in saliva.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
calcipotriol gel and photodynamic therapy
What this could lead to
If it works, this could point toward a non-surgical treatment for oral leukoplakia, potentially lowering the risk of oral cancer.
What could go wrong
This is a small, early-phase trial with only 30 people, so results may not apply to everyone. The treatments might not shrink lesions or could cause side effects like irritation.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Faculty of Dentistry, Alexandria University
Alexandria, 21527, Egypt