Could a High-Fat diet help cancer immunotherapy work better?

NCT ID NCT06391099

Terminated Disease control Sponsor: Ohio State University Comprehensive Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-phase trial is testing whether a ketogenic diet (low carbs, high fat) can safely help immunotherapy drugs work better in people with advanced melanoma or kidney cancer. About 60 participants will follow the diet while receiving standard immunotherapy. The main goals are to see if the diet is safe and if people can stick with it.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ketogenic diet
What this could lead to: If it works, this could point toward a simple dietary change that helps immunotherapy work better for some cancers.
What could go wrong: This is a very early phase I trial focused on safety and feasibility, not yet on effectiveness. The study is currently suspended, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

melanoma metastatic melanoma renal cell adenocarcinoma renal cell carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CLINICAL STAGE IV CUTANEOUS MELANOMA AJCC V8 METASTATIC CUTANEOUS MELANOMA METASTATIC RENAL CELL CARCINOMA STAGE IV RENAL CELL CANCER AJCC V8

Contacts and locations

Locations

Ohio State University Comprehensive Cancer Center

Columbus, Ohio, 43210, United States

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