STAGE IV RENAL CELL CANCER AJCC V8

This trial is for people whose kidney cancer has spread. It aims to find out if removing the original kidney tumor with surgery, on top of standard immunotherapy drug combinations, helps patients live longer than using the drugs alone. About 364 participants will be randomly assi…

This early-stage trial is testing the safety of combining a wearable device that uses electric fields to disrupt cancer cells with different drug combinations. It is for adults with advanced cancers in the abdomen or chest that have spread and who have run out of standard treatme…

This study aims to find the best radiation method for treating cancer that has spread to the brain. It compares giving one large radiation dose versus spreading the same total radiation over three smaller treatments. Researchers want to see which approach better controls the brai…

This study is for people with advanced kidney cancer that has spread and is not recommended for surgery. It tests whether adding a short, highly focused course of radiation to the main kidney tumor, while patients receive standard immunotherapy drugs, helps control the cancer bet…

This study is testing a combination of three drugs—cabozantinib, nivolumab, and ipilimumab—for patients with rare types of bladder, kidney, penile, and other urinary tract cancers that have spread. The goal is to see if this three-drug approach can shrink tumors and control the d…

This early-stage study is testing whether adding a specific gut bacteria supplement, called EXL01, makes standard immunotherapy drugs (nivolumab and ipilimumab) safer and more effective for people with advanced kidney cancer that has spread. The goal is to see if changing the gut…

This study is testing a new, personalized vaccine designed to target the unique proteins on a patient's own cancer cells. It is being given alongside an existing immunotherapy drug (pembrolizumab) to see if the combination is safe and can help control advanced solid tumors that h…

This study is testing whether giving a cancer immunotherapy treatment called nivolumab as an injection at home is a safe and practical alternative to receiving it at a clinic. It aims to see if home treatment reduces the burden of travel and improves quality of life for patients …

This study is testing a combination of three drugs—bevacizumab, erlotinib, and atezolizumab—to see if they can control or shrink advanced kidney cancers linked to a hereditary condition (HLRCC) or a specific type called papillary renal cell cancer. The trial aims to enroll 65 pat…

This study is testing whether following a strict high-fat, low-carbohydrate (ketogenic) diet is safe and feasible for patients with advanced melanoma or kidney cancer who are receiving immunotherapy. Researchers want to see if changing the body's main fuel source from sugar to fa…

This study is testing whether adding a gel made from inulin, a common dietary fiber, makes standard immunotherapy drugs more effective for people with advanced kidney cancer. Researchers think improving gut bacteria health might help the immune system fight cancer better. The tri…

This study is testing if adding a freezing procedure (cryoablation) to standard radiation therapy works better to relieve pain from cancer that has spread to the bones. Researchers will compare the combination treatment to radiation alone in 40 patients with advanced cancers. The…

This study aims to collect tumor tissue samples from patients with various cancers to test a new diagnostic platform called Elephas. The goal is to see how accurately this tool can predict whether patients will respond to immunotherapy treatments before they begin. Researchers wi…