Could a gut bacteria boost cancer immunotherapy? new trial launches
NCT ID NCT07128680
First seen Jun 27, 2026 · Last updated Jul 17, 2026 · Updated 2 times
Summary
This early-phase trial tests whether adding a live bacteria supplement (EXL01) to standard immunotherapy (nivolumab and ipilimumab) is safe and more effective for people with metastatic kidney cancer. About 33 participants will receive either the immunotherapy alone or with the supplement. The goal is to see if the bacteria can improve the immune response against the tumor.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- nivolumab, ipilimumab, and EXL01 (a live bacterial supplement)
- What this could lead to
- If it works, this could point toward a way to boost the immune system's attack on kidney cancer by adding a gut bacteria supplement to standard immunotherapy.
- What could go wrong
- This is a very early (Phase 1) and small (33 people) trial, so it is mainly checking safety. The bacteria supplement may not help, and side effects from the immunotherapy can be serious.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
City of Hope Medical Center
RECRUITINGDuarte, California, 91010, United States
-
City of Hope Medical Center
RECRUITINGIrvine, California, 92618, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a pill rewrite the genetic story of resistant kidney cancer?
- Can a Two-Pronged immune attack shrink kidney tumors before surgery?
- Can a rapid drug switch outsmart advanced kidney cancer?
- Can a tracer that hunts unstable iron light up hidden tumors?
- Can a pill that starves tumors of oxygen help fight advanced cancer?
- Old drug, new hope: mercaptopurine tested against rare cancer syndrome