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Could probiotics help ovarian cancer patients on chemo?

NCT ID NCT07144826

Recruiting now Disease control Sponsor: Ohio State University Comprehensive Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether taking probiotic supplements can improve the gut and vaginal microbiome in women with advanced or recurrent ovarian cancer who are receiving platinum-based chemotherapy. About 161 participants will be randomly assigned to receive either probiotics or a placebo. The goal is to see if probiotics can help maintain a healthy microbiome, which may improve quality of life and reduce symptoms during treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Probiotic supplement
What this could lead to
If it works, this could point toward a way to improve gut health and reduce side effects during chemotherapy for ovarian cancer.
What could go wrong
This is a very early phase 1 trial, so it's mainly checking safety and feasibility. The probiotic may not change outcomes or symptoms, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

ovarian cancer ovarian carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED OVARIAN CARCINOMA RECURRENT OVARIAN CARCINOMA STAGE II OVARIAN CANCER AJCC V8 STAGE III OVARIAN CANCER AJCC V8 STAGE IV OVARIAN CANCER AJCC V8

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Ohio State University Comprehensive Cancer Center

    RECRUITING

    Columbus, Ohio, 43210, United States

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