Brain training before CAR-T may protect memory, study hopes

NCT ID NCT07609030

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests an online cognitive training program called I-CAN in 90 adults with relapsed multiple myeloma or B-cell non-Hodgkin lymphoma who are about to receive CAR-T cell therapy. The training aims to reduce the memory, attention, and thinking problems that often follow cancer treatment. Participants will do the training before and after their CAR-T infusion, and researchers will track how many complete the program and whether they report better cognitive function.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

online cognitive training program (I-CAN)

What this could lead to

If it works, this could point toward a way to reduce memory and thinking problems caused by cancer treatment.

What could go wrong

This is a small, early feasibility study, so it may not show clear cognitive benefits. The training is time-consuming and not all patients may stick with it.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

B-cell neoplasm B-cell non-Hodgkin lymphoma plasma cell myeloma refractory plasma cell neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Ohio State University Comprehensive Cancer Center

    RECRUITING

    Columbus, Ohio, 43210, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact