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Brain training before CAR-T may protect memory, study hopes

NCT ID NCT07609030

Recruiting now Symptom relief Sponsor: Ohio State University Comprehensive Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests an online cognitive training program called I-CAN in 90 adults with relapsed multiple myeloma or B-cell non-Hodgkin lymphoma who are about to receive CAR-T cell therapy. The training aims to reduce the memory, attention, and thinking problems that often follow cancer treatment. Participants will do the training before and after their CAR-T infusion, and researchers will track how many complete the program and whether they report better cognitive function.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
online cognitive training program (I-CAN)
What this could lead to
If it works, this could point toward a way to reduce memory and thinking problems caused by cancer treatment.
What could go wrong
This is a small, early feasibility study, so it may not show clear cognitive benefits. The training is time-consuming and not all patients may stick with it.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

B-cell neoplasm B-cell non-Hodgkin lymphoma plasma cell myeloma refractory plasma cell neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RECURRENT B-CELL NON-HODGKIN LYMPHOMA RECURRENT MULTIPLE MYELOMA REFRACTORY B-CELL NON-HODGKIN LYMPHOMA REFRACTORY MULTIPLE MYELOMA

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Ohio State University Comprehensive Cancer Center

    RECRUITING

    Columbus, Ohio, 43210, United States

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