New combo therapy aims to strengthen spine and fight cancer spread

NCT ID NCT05178472

Recruiting now Disease control Sponsor: Ohio State University Comprehensive Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is for people with cancer that has spread to the spine. It tests whether adding a procedure called vertebroplasty (which repairs broken spine bones) to standard radiation and immunotherapy can help prevent fractures and improve survival. About 200 participants will receive different combinations of these treatments. The goal is to find a better way to control the disease and maintain quality of life.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: vertebroplasty (a procedure to repair broken spine bones) combined with stereotactic radiosurgery (precise radiation) and/or immunotherapy
What this could lead to: If successful, this could lead to a better standard treatment for spinal metastases that reduces fractures and improves survival and quality of life.
What could go wrong: This is an early-phase trial with no phase designation, so results are uncertain. The combination of procedures may increase risks like infection or nerve damage, and benefits may not be confirmed in larger studies.

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Conditions

The condition(s) this trial relates to.

cancer hematopoietic and lymphoid cell neoplasm hematopoietic and lymphoid system neoplasm metastatic malignant neoplasm in the spinal cord

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEMATOPOIETIC AND LYMPHOID CELL NEOPLASM MALIGNANT SOLID NEOPLASM METASTATIC MALIGNANT NEOPLASM IN THE SPINE

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Ohio State University Comprehensive Cancer Center
RECRUITING

Columbus, Ohio, 43210, United States

Contact Email: •••••@•••••

Contact

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