HEMATOPOIETIC AND LYMPHOID CELL NEOPLASM

This study is for people who have both an autoimmune disorder (like rheumatoid arthritis, lupus, or multiple sclerosis) and advanced cancer that has spread or cannot be removed. It tests a drug called nivolumab, which helps the immune system fight cancer, given alone or with othe…

This early-stage study tests whether specially grown donor immune cells can safely treat adenovirus infections in people with weakened immune systems, such as those with blood cancers. The cells are made from donated blood and matched as closely as possible to the patient. The ma…

This study tests whether adding special cells from donated umbilical cord blood to a standard drug (ruxolitinib) can better control a serious complication called graft-versus-host disease (GVHD) that does not respond to steroids. About 24 people aged 12 to 80 with this condition …

This early-stage trial tests whether specially designed immune cells (T-cells) can safely control viral infections like CMV, BK virus, or COVID-19 in cancer patients with weakened immune systems. The cells are modified to resist common anti-rejection drugs and target specific vir…

This study tests whether combining two antiviral drugs, baloxavir and oseltamivir, can better treat severe flu in people who have had a stem cell transplant or have blood cancer. About 60 participants will receive the combo or standard care. The goal is to see if the combination …

This study tests whether stem cells from a donor can help control heart failure in people whose hearts were weakened by a type of chemotherapy called anthracyclines. About 72 adults with low heart function will receive either standard care alone or standard care plus stem cells g…

This study looks at whether adding a procedure called vertebroplasty (which repairs broken spine bones) to radiation therapy can help patients whose cancer has spread to the spine. The goal is to reduce bone fractures and improve survival and quality of life. About 200 adults wit…

This study tests whether infusions of stem cells from donated umbilical cord blood can help control severe pneumonia caused by COVID-19 in cancer patients. About 70 adults with moderate to critical illness will receive either stem cells plus standard care or standard care alone. …

This study tests a radioactive antibody (211At-BC8-B10) followed by a donor stem cell transplant for people with high-risk leukemia or myelodysplastic syndrome (MDS) that has come back or not responded to treatment. The antibody targets cancer cells and delivers radiation, then c…

This study tests whether the antiviral drug letermovir can prevent cytomegalovirus (CMV) infection in children and teens who have had a stem cell transplant. About 105 participants aged 2 to 17 who are CMV-positive will take letermovir after transplant. The goal is to see if the …

This study looks at whether expressive writing can help cancer survivors cope with stress, especially during tough times like the COVID-19 pandemic. About 414 adults diagnosed with cancer in the last 3 years will participate online from home. They will write about their experienc…

This study tests whether alteplase, a drug that dissolves blood clots, can improve drainage of fluid around the lungs and reduce shortness of breath in cancer patients. About 30 adults with malignant pleural effusion that is not draining well will receive either alteplase or a pl…

This study tests whether combining a nerve pain drug (duloxetine) with neurofeedback—a therapy that teaches you to change your own brain waves—can better relieve chemotherapy-induced nerve damage than either treatment alone. About 380 adults with nerve pain from past chemo will b…

This study tests whether using a mask to deliver pressurized oxygen (non-invasive ventilation) can help cancer patients with respiratory failure breathe better and avoid needing a breathing tube. About 256 adults with cancer and low oxygen levels will be randomly assigned to rece…

This study is testing a program called TEAM Me that uses tokens and rewards to encourage exercise in children and young adults with cancer who are recovering from a stem cell transplant. The goal is to see if the program is doable and safe, and if it helps improve physical fitnes…

This study looks at how a video-based mentoring program called Project ECHO helps doctors in underserved areas of Kenya, Nigeria, Ghana, South Africa, India, and Ethiopia provide better palliative care to advanced cancer patients. Researchers will track changes in patients' quali…

This study analyzes tumor samples from 12,000 cancer patients to find gene changes (mutations). The goal is to match each person with a clinical trial or therapy that targets their specific cancer type. Researchers will also build a database of mutations to improve future treatme…

This study brings together a panel of prostate cancer experts to agree on the most important pieces of information that should be included in medical reports. The goal is to create a standard way of reporting key data in electronic health records, which could help doctors better …

This study follows 250 people who have had a donor stem cell transplant to see if respiratory viruses lead to a lung condition called bronchiolitis obliterans syndrome (BOS). Participants use a simple home device to check their lung function regularly. The goal is to catch lung p…

This study tracks side effects and treatment results in 170 advanced cancer patients receiving anti-VEGF therapy. Researchers want to see if certain side effects are linked to how well the cancer responds. The goal is to help doctors better predict outcomes and manage treatment.

This study looks at how the COVID-19 pandemic changed the emotional, financial, physical, and social well-being of teens and young adults who have or had cancer. Researchers will survey 600 participants to understand their stress and health behaviors during the pandemic. The goal…

This study collects blood and tissue samples from 2000 people—some with cancer, some without—to help researchers develop and improve blood tests that can detect many types of cancer early. Participants provide samples that are stored and later used to test new diagnostic methods.…

This study collects blood, tissue, and bone marrow samples from people with cancer or blood disorders, as well as healthy volunteers. Researchers will use these samples to study how the immune system changes during different treatments, including immunotherapy and chemotherapy. T…

This study follows 100 adults with blood cancers who receive whole brain radiation therapy to see how it affects their memory and thinking skills. Researchers will test cognitive function over time using standard assessments. The goal is to better understand the side effects of t…

This study gathers information on short- and long-term side effects from proton therapy in adults with various cancers. Researchers will collect data from up to 5,000 participants to better understand and predict these side effects. The goal is to improve future treatment plannin…

This study surveys 250 U.S. pulmonologists to learn how the COVID-19 pandemic changed their lung procedures, staffing, and clinic operations. The goal is to help lung programs improve and guide future research for better pandemic preparedness. Participants are doctors who are mem…

This study looks at how the natural bacteria in your gut (the microbiome) can change the way cancer treatments work. Researchers will collect samples from 3,000 cancer patients to find links between gut bacteria and treatment success. No new drugs are tested—the goal is to learn …

This study gathers information from 100 adults with blood cancers who receive CAR-T therapy and/or radiation as part of their standard care. The goal is to learn how to better choose patients, timing, and doses for these treatments. Researchers will track outcomes like disease pr…