Cord blood cells join forces with drug to fight transplant complication
NCT ID NCT04744116
First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 2 times
Summary
This early study tests whether adding special cells from donated umbilical cord blood (called mesenchymal stromal cells) to the drug ruxolitinib can help control severe graft-versus-host disease (GVHD) that hasn't improved with steroids. GVHD is a serious complication where donor immune cells attack the patient's body after a stem cell transplant. The trial will enroll 24 people aged 12 to 80 and compare the combination therapy against ruxolitinib alone, looking at response rates and side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- cord blood tissue-derived mesenchymal stromal cells (cb-MSCs) combined with ruxolitinib
- What this could lead to
- If it works, this could point toward a better treatment for severe graft-versus-host disease that doesn't respond to steroids.
- What could go wrong
- This is a very early, small pilot study with only 24 people, so results may not apply widely. There is also a risk of side effects from the cell infusion or the drug.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
M D Anderson Cancer Center
RECRUITINGHouston, Texas, 77030, United States
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