Can a Two-Step stem cell transplant tame Graft-Versus-Host disease?
NCT ID NCT03712878
First seen Jul 23, 2026 · Last updated Jul 24, 2026 · Updated 1 time
Summary
This phase 2 trial tests a two-step approach to stem cell transplantation for people with blood cancers. The method separates the infusion of donor lymphocytes from stem cells, aiming to better control the dose and reduce the risk of graft-versus-host disease, a serious complication. Participants receive chemotherapy and total-body radiation before the transplant, followed by drugs to suppress immune reactions. The study focuses on whether this strategy can achieve high levels of donor immune cells in the patient's body quickly and safely.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- a two-step stem cell transplant with total-body irradiation, donor lymphocyte infusion, and cyclophosphamide
- What this could lead to
- If successful, this approach could make stem cell transplants safer and more effective for people with blood cancers, potentially leading to higher cure rates with fewer complications.
- What could go wrong
- This is a small early-phase trial, so results may not apply broadly. Risks include graft-versus-host disease, infection, and transplant failure.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Philadelphia, Pennsylvania, 19107, United States
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