Can adding radiation boost immunotherapy against tough cancers?
NCT ID NCT02888743
First seen Jun 24, 2026 · Last updated Jul 31, 2026 · Updated 4 times
Summary
This phase 2 trial tests whether combining two immunotherapy drugs (durvalumab and tremelimumab) with or without radiation therapy can shrink tumors in people with metastatic colorectal or non-small cell lung cancer. About 110 participants will receive the drugs alone or with high or low-dose radiation. The study aims to see if the combination improves response rates and delays cancer progression.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Durvalumab and tremelimumab (immunotherapy drugs) with or without radiation therapy
- What this could lead to
- If successful, this could point toward a new treatment option that combines immunotherapy with radiation to better control metastatic colorectal and lung cancers.
- What could go wrong
- This is an early phase 2 trial with only 110 participants, so results may not apply to all patients. Immunotherapy can cause serious immune-related side effects, and the added benefit of radiation is not yet proven.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Beth Israel Deaconess Medical Center
Boston, Massachusetts, 02215, United States
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Brigham and Women's Hospital
Boston, Massachusetts, 02115, United States
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Cleveland Clinic Foundation
Cleveland, Ohio, 44195, United States
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Dana-Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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Duke University Medical Center
Durham, North Carolina, 27710, United States
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Emory Saint Joseph's Hospital
Atlanta, Georgia, 30342, United States
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Emory University Hospital Midtown
Atlanta, Georgia, 30308, United States
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Emory University Hospital/Winship Cancer Institute
Atlanta, Georgia, 30322, United States
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Los Angeles General Medical Center
Los Angeles, California, 90033, United States
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Massachusetts General Hospital Cancer Center
Boston, Massachusetts, 02114, United States
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Mayo Clinic Hospital in Arizona
Phoenix, Arizona, 85054, United States
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Mayo Clinic in Arizona
Scottsdale, Arizona, 85259, United States
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Mayo Clinic in Florida
Jacksonville, Florida, 32224-9980, United States
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Mayo Clinic in Rochester
Rochester, Minnesota, 55905, United States
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Ohio State University Comprehensive Cancer Center
Columbus, Ohio, 43210, United States
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Rutgers Cancer Institute of New Jersey
New Brunswick, New Jersey, 08903, United States
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Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital
New Brunswick, New Jersey, 08903, United States
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Siteman Cancer Center at Saint Peters Hospital
City of Saint Peters, Missouri, 63376, United States
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Siteman Cancer Center at West County Hospital
Creve Coeur, Missouri, 63141, United States
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Siteman Cancer Center-South County
St Louis, Missouri, 63129, United States
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Smilow Cancer Center/Yale-New Haven Hospital
New Haven, Connecticut, 06510, United States
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Smilow Cancer Hospital Care Center - Guilford
Guilford, Connecticut, 06437, United States
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Smilow Cancer Hospital Care Center - Waterford
Waterford, Connecticut, 06385, United States
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Smilow Cancer Hospital Care Center at Saint Francis
Hartford, Connecticut, 06105, United States
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Smilow Cancer Hospital Care Center-Trumbull
Trumbull, Connecticut, 06611, United States
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Thomas Jefferson University Hospital
Philadelphia, Pennsylvania, 19107, United States
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UNC Lineberger Comprehensive Cancer Center
Chapel Hill, North Carolina, 27599, United States
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UPMC Hillman Cancer Center
Pittsburgh, Pennsylvania, 15232, United States
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USC / Norris Comprehensive Cancer Center
Los Angeles, California, 90033, United States
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University Health Network-Princess Margaret Hospital
Toronto, Ontario, M5G 2M9, Canada
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University of California Davis Comprehensive Cancer Center
Sacramento, California, 95817, United States
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University of Kentucky/Markey Cancer Center
Lexington, Kentucky, 40536, United States
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University of Maryland/Greenebaum Cancer Center
Baltimore, Maryland, 21201, United States
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University of Virginia Cancer Center
Charlottesville, Virginia, 22908, United States
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University of Wisconsin Carbone Cancer Center - University Hospital
Madison, Wisconsin, 53792, United States
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VCU Massey Comprehensive Cancer Center
Richmond, Virginia, 23298, United States
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Vanderbilt University/Ingram Cancer Center
Nashville, Tennessee, 37232, United States
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Washington University School of Medicine
St Louis, Missouri, 63110, United States
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Wayne State University/Karmanos Cancer Institute
Detroit, Michigan, 48201, United States
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Weisberg Cancer Treatment Center
Farmington Hills, Michigan, 48334, United States
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Yale University
New Haven, Connecticut, 06520, United States
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Yale-New Haven Hospital North Haven Medical Center
North Haven, Connecticut, 06473, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a pill boost the immune system to fight Hard-to-Treat cancers?
- Experimental drug combo targets Hard-to-Treat GI cancers
- New imaging agent may help doctors see which lung tumors are still growing during immunotherapy
- Could a pill help the liver regrow and make more cancer surgeries possible?
- Brain cancer trial halted early: can Memory-Sparing radiation help when tumors return?
- Can a smaller dose of this cancer drug still work? new trial aims to find out