Brain cancer trial halted early: can Memory-Sparing radiation help when tumors return?
NCT ID NCT04588246
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase III trial compared two radiation strategies for cancer that had spread to the brain and returned in new spots after initial radiosurgery. One group received focused radiation only to the new tumors, while the other received whole brain radiation that avoided the memory center, plus a drug to protect thinking. The study was stopped early after enrolling only 19 people, so it cannot provide clear answers.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
radiation therapy (whole brain radiotherapy with hippocampal avoidance and memantine, or stereotactic radiosurgery)
What this could lead to
If successful, this could show that adding whole brain radiotherapy with memory-sparing techniques helps control brain metastases that come back after initial radiosurgery.
What could go wrong
The trial was terminated early with only 19 participants, so results are very limited and no firm conclusions can be drawn. The approach also carries risks of cognitive side effects from radiation.
Disclaimer
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the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Banner University Medical Center - Tucson
Tucson, Arizona, 85719, United States
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CHUM - Centre Hospitalier de l'Universite de Montreal
Montreal, Quebec, H2X 3E4, Canada
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California Pacific Medical Center-Pacific Campus
San Francisco, California, 94115, United States
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Carle Cancer Center
Urbana, Illinois, 61801, United States
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Carle Physician Group-Effingham
Effingham, Illinois, 62401, United States
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Carle Physician Group-Mattoon/Charleston
Mattoon, Illinois, 61938, United States
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Carle at The Riverfront
Danville, Illinois, 61832, United States
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Central Maryland Radiation Oncology in Howard County
Columbia, Maryland, 21044, United States
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Chelsea Hospital
Chelsea, Michigan, 48118, United States
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Christiana Care Health System-Christiana Hospital
Newark, Delaware, 19718, United States
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Christiana Care Health System-Concord Health Center
Chadds Ford, Pennsylvania, 19317, United States
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City of Hope Antelope Valley
Lancaster, California, 93534, United States
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City of Hope Comprehensive Cancer Center
Duarte, California, 91010, United States
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City of Hope Corona
Corona, California, 92882, United States
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City of Hope South Bay
Torrance, California, 90503, United States
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City of Hope South Pasadena
South Pasadena, California, 91030, United States
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City of Hope Upland
Upland, California, 91786, United States
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City of Hope at Irvine Lennar
Irvine, California, 92618, United States
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Covenant Medical Center-Lakeside
Lubbock, Texas, 79410, United States
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Delaware Clinical and Laboratory Physicians PA
Newark, Delaware, 19713, United States
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Drexel Town Square Health Center
Oak Creek, Wisconsin, 53154, United States
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Froedtert Menomonee Falls Hospital
Menomonee Falls, Wisconsin, 53051, United States
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Froedtert West Bend Hospital/Kraemer Cancer Center
West Bend, Wisconsin, 53095, United States
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Geisinger Cancer Services-Pottsville
Pottsville, Pennsylvania, 17901, United States
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Geisinger Medical Center
Danville, Pennsylvania, 17822, United States
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Geisinger Medical Oncology-Lewisburg
Lewisburg, Pennsylvania, 17837, United States
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Helen F Graham Cancer Center
Newark, Delaware, 19713, United States
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Lankenau Medical Center
Wynnewood, Pennsylvania, 19096, United States
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Mayo Clinic in Florida
Jacksonville, Florida, 32224-9980, United States
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MedStar Franklin Square Medical Center/Weinberg Cancer Institute
Baltimore, Maryland, 21237, United States
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Medical College of Wisconsin
Milwaukee, Wisconsin, 53226, United States
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Medical Oncology Hematology Consultants PA
Newark, Delaware, 19713, United States
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Medical University of South Carolina
Charleston, South Carolina, 29425, United States
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Memorial Hospital West
Pembroke Pines, Florida, 33028, United States
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Northwell Health/Center for Advanced Medicine
Lake Success, New York, 11042, United States
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Northwestern Medicine Cancer Center Delnor
Geneva, Illinois, 60134, United States
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Northwestern Medicine Cancer Center Kishwaukee
DeKalb, Illinois, 60115, United States
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Northwestern Medicine Cancer Center Warrenville
Warrenville, Illinois, 60555, United States
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Northwestern University
Chicago, Illinois, 60611, United States
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Ohio State University Comprehensive Cancer Center
Columbus, Ohio, 43210, United States
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Pamela Youde Nethersole Eastern Hospital
Chai Wan, Hong Kong
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Prisma Health Cancer Institute - Faris
Greenville, South Carolina, 29605, United States
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Riddle Memorial Hospital
Media, Pennsylvania, 19063, United States
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Rush University Medical Center
Chicago, Illinois, 60612, United States
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Sanford Bismarck Medical Center
Bismarck, North Dakota, 58501, United States
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Sanford Broadway Medical Center
Fargo, North Dakota, 58122, United States
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Sanford Roger Maris Cancer Center
Fargo, North Dakota, 58122, United States
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Siteman Cancer Center at Christian Hospital
St Louis, Missouri, 63136, United States
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Siteman Cancer Center at Saint Peters Hospital
City of Saint Peters, Missouri, 63376, United States
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Siteman Cancer Center at West County Hospital
Creve Coeur, Missouri, 63141, United States
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Siteman Cancer Center-South County
St Louis, Missouri, 63129, United States
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State University of New York Upstate Medical University
Syracuse, New York, 13210, United States
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Sutter Cancer Centers Radiation Oncology Services-Roseville
Roseville, California, 95661, United States
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Sutter Medical Center Sacramento
Sacramento, California, 95816, United States
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Sutter Roseville Medical Center
Roseville, California, 95661, United States
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The Carle Foundation Hospital
Urbana, Illinois, 61801, United States
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Trinity Health IHA Medical Group Hematology Oncology - Brighton
Brighton, Michigan, 48114, United States
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Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
Chelsea, Michigan, 48118, United States
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Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
Ypsilanti, Michigan, 48197, United States
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Trinity Health Saint Joseph Mercy Hospital Ann Arbor
Ann Arbor, Michigan, 48106, United States
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Tufts Medical Center
Boston, Massachusetts, 02111, United States
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UM Baltimore Washington Medical Center/Tate Cancer Center
Glen Burnie, Maryland, 21061, United States
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UM Sylvester Comprehensive Cancer Center at Coral Gables
Coral Gables, Florida, 33146, United States
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UM Sylvester Comprehensive Cancer Center at Deerfield Beach
Deerfield Beach, Florida, 33442, United States
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UM Upper Chesapeake Medical Center
Bel Air, Maryland, 21014, United States
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UPMC Cancer Centers - Arnold Palmer Pavilion
Greensburg, Pennsylvania, 15601, United States
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UPMC Memorial
York, Pennsylvania, 17408, United States
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UPMC-Shadyside Hospital
Pittsburgh, Pennsylvania, 15232, United States
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University of Arizona Cancer Center-North Campus
Tucson, Arizona, 85719, United States
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University of Chicago Comprehensive Cancer Center
Chicago, Illinois, 60637, United States
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University of Maryland/Greenebaum Cancer Center
Baltimore, Maryland, 21201, United States
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University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami, Florida, 33136, United States
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University of Mississippi Medical Center
Jackson, Mississippi, 39216, United States
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University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, 73104, United States
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University of Rochester
Rochester, New York, 14642, United States
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University of Wisconsin Carbone Cancer Center - University Hospital
Madison, Wisconsin, 53792, United States
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Upstate Cancer Center at Verona
Verona, New York, 13478, United States
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Virginia Commonwealth University/Massey Cancer Center
Richmond, Virginia, 23298, United States
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Wake Forest University Health Sciences
Winston-Salem, North Carolina, 27157, United States
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Washington University School of Medicine
St Louis, Missouri, 63110, United States
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West Virginia University Healthcare
Morgantown, West Virginia, 26506, United States